Peptide-grafted polymers as artificial converter of cellular signals

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Intracellular signal transduction systems consisting of sophisticated molecular networks are essential to provide almost all cellular functions. Any abnormal activation of enzymes included in this network can be directly linked to various disease states. Therefore, cellular function can be altered if we can modulate this signal transduction process. In this context, artificial signal converters, which respond to particular abnormal signaling to activate transgene transcription, are introduced. Such molecular systems use polymer materials grafted with cationic peptides, which are a specific substrate of target protein kinase or protease. This concept which is called D-RECS, DDS in response to cellular signals, could have potential for design of disease cell specific therapeutic or diagnostic (imaging) systems using pathological signaling as a target. Molecular design and structural factors affecting signal response in such systems are discussed.

Original languageEnglish
Pages (from-to)12-21
Number of pages10
JournalBulletin of the Chemical Society of Japan
Volume90
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Signal transduction
Polymers
Peptides
Transcription
Imaging systems
Protein Kinases
Peptide Hydrolases
Chemical activation
Substrates
Enzymes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Peptide-grafted polymers as artificial converter of cellular signals. / Katayama, Yoshiki.

In: Bulletin of the Chemical Society of Japan, Vol. 90, No. 1, 01.01.2017, p. 12-21.

Research output: Contribution to journalArticle

@article{3ec3583e8d5243c397a84b9b2ef7888a,
title = "Peptide-grafted polymers as artificial converter of cellular signals",
abstract = "Intracellular signal transduction systems consisting of sophisticated molecular networks are essential to provide almost all cellular functions. Any abnormal activation of enzymes included in this network can be directly linked to various disease states. Therefore, cellular function can be altered if we can modulate this signal transduction process. In this context, artificial signal converters, which respond to particular abnormal signaling to activate transgene transcription, are introduced. Such molecular systems use polymer materials grafted with cationic peptides, which are a specific substrate of target protein kinase or protease. This concept which is called D-RECS, DDS in response to cellular signals, could have potential for design of disease cell specific therapeutic or diagnostic (imaging) systems using pathological signaling as a target. Molecular design and structural factors affecting signal response in such systems are discussed.",
author = "Yoshiki Katayama",
year = "2017",
month = "1",
day = "1",
doi = "10.1246/bcsj.20160307",
language = "English",
volume = "90",
pages = "12--21",
journal = "Bulletin of the Chemical Society of Japan",
issn = "0009-2673",
publisher = "The Chemical Society of Japan",
number = "1",

}

TY - JOUR

T1 - Peptide-grafted polymers as artificial converter of cellular signals

AU - Katayama, Yoshiki

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Intracellular signal transduction systems consisting of sophisticated molecular networks are essential to provide almost all cellular functions. Any abnormal activation of enzymes included in this network can be directly linked to various disease states. Therefore, cellular function can be altered if we can modulate this signal transduction process. In this context, artificial signal converters, which respond to particular abnormal signaling to activate transgene transcription, are introduced. Such molecular systems use polymer materials grafted with cationic peptides, which are a specific substrate of target protein kinase or protease. This concept which is called D-RECS, DDS in response to cellular signals, could have potential for design of disease cell specific therapeutic or diagnostic (imaging) systems using pathological signaling as a target. Molecular design and structural factors affecting signal response in such systems are discussed.

AB - Intracellular signal transduction systems consisting of sophisticated molecular networks are essential to provide almost all cellular functions. Any abnormal activation of enzymes included in this network can be directly linked to various disease states. Therefore, cellular function can be altered if we can modulate this signal transduction process. In this context, artificial signal converters, which respond to particular abnormal signaling to activate transgene transcription, are introduced. Such molecular systems use polymer materials grafted with cationic peptides, which are a specific substrate of target protein kinase or protease. This concept which is called D-RECS, DDS in response to cellular signals, could have potential for design of disease cell specific therapeutic or diagnostic (imaging) systems using pathological signaling as a target. Molecular design and structural factors affecting signal response in such systems are discussed.

UR - http://www.scopus.com/inward/record.url?scp=85027008056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027008056&partnerID=8YFLogxK

U2 - 10.1246/bcsj.20160307

DO - 10.1246/bcsj.20160307

M3 - Article

AN - SCOPUS:85027008056

VL - 90

SP - 12

EP - 21

JO - Bulletin of the Chemical Society of Japan

JF - Bulletin of the Chemical Society of Japan

SN - 0009-2673

IS - 1

ER -