Peptide nanospheres self-assembled from a modified β-annulus peptide of Sesbania mosaic virus

Kazunori Matsuura, Yusaku Mizuguchi, Nobuo Kimizuka

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A novel β-annulus peptide of Sesbania mosaic virus bearing an FKFE sequence at the C terminus was synthesized, and its self-assembling behavior in water was investigated. Dynamic light scattering and transmission electron microscopy showed that the β-annulus peptide bearing an FKFE sequence self-assembled into approximately 30 nm nanospheres in water at pH 3.8, whereas the β-annulus peptide without the FKFE sequence afforded only irregular aggregates. The peptide nanospheres possessed a definite critical aggregation concentration (CAC = 26 μM), above which the size of nanospheres were nearly unaffected by the peptide concentration. The formation of peptide nanospheres was significantly affected by pH; the peptide did not form any assemblies at pH 2.2, whereas larger aggregates were formed at pH 6.4–11.6.

Original languageEnglish
Pages (from-to)470-475
Number of pages6
JournalBiopolymers
DOIs
Publication statusPublished - Nov 4 2016

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

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