Peptide vector for gene delivery with high affinity for phosphatidylserine

Shinichi Kuriyama, Yasushi Taguchi, Kanako Nishimura, Kiyoshi Mizuguchi, Kazutoshi Kobayashi, Yoshiki Katayama, Kazutoshi Yanagibashi, Takuro Niidome

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Since phosphatidylserine (PS) is known to translocate to the external face of the plasma membrane when the cell membrane becomes disordered, we decided to focus our attention on PS as a target molecule for gene delivery. In this paper, the novel peptide Td3701 was designed, synthesized, and characterized for its physico-chemico-biological properties. Td3701 simultaneously exhibited both characters as a DNA carrier and a sensor probe for active targeting, which seemed to be triggered by structural changes in the presence of PS. This is a very unique character among nonviral vectors, and it is believed that Td3701 could be used for selective gene delivery.

    Original languageEnglish
    Pages (from-to)626-632
    Number of pages7
    JournalJournal of Peptide Science
    Volume12
    Issue number10
    DOIs
    Publication statusPublished - Oct 1 2006

    All Science Journal Classification (ASJC) codes

    • Structural Biology
    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmacology
    • Drug Discovery
    • Organic Chemistry

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