Peptide vector for gene delivery with high affinity for phosphatidylserine

Shinichi Kuriyama, Yasushi Taguchi, Kanako Nishimura, Kiyoshi Mizuguchi, Kazutoshi Kobayashi, Yoshiki Katayama, Kazutoshi Yanagibashi, Takuro Niidome

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Since phosphatidylserine (PS) is known to translocate to the external face of the plasma membrane when the cell membrane becomes disordered, we decided to focus our attention on PS as a target molecule for gene delivery. In this paper, the novel peptide Td3701 was designed, synthesized, and characterized for its physico-chemico-biological properties. Td3701 simultaneously exhibited both characters as a DNA carrier and a sensor probe for active targeting, which seemed to be triggered by structural changes in the presence of PS. This is a very unique character among nonviral vectors, and it is believed that Td3701 could be used for selective gene delivery.

Original languageEnglish
Pages (from-to)626-632
Number of pages7
JournalJournal of Peptide Science
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 1 2006

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Kuriyama, S., Taguchi, Y., Nishimura, K., Mizuguchi, K., Kobayashi, K., Katayama, Y., Yanagibashi, K., & Niidome, T. (2006). Peptide vector for gene delivery with high affinity for phosphatidylserine. Journal of Peptide Science, 12(10), 626-632. https://doi.org/10.1002/psc.768