TY - JOUR
T1 - Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips
AU - Noda, Toshihiko
AU - Sasagawa, Kiyotaka
AU - Tokuda, Takashi
AU - Terasawa, Yasuo
AU - Tashiro, Hiroyuki
AU - Kanda, Hiroyuki
AU - Fujikado, Takashi
AU - Ohta, Jun
N1 - Funding Information:
Part of this study stems from the “Brain Machine Interface Development” study carried out under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan. It is also supported by a Grant-in-Aid for Young Scientists (B), # 23760312 , from the Japan Society for the Promotion of Science .
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/5/1
Y1 - 2014/5/1
N2 - The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis.
AB - The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis.
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U2 - 10.1016/j.sna.2014.03.001
DO - 10.1016/j.sna.2014.03.001
M3 - Article
AN - SCOPUS:84896941647
VL - 211
SP - 27
EP - 37
JO - Sensors and Actuators A: Physical
JF - Sensors and Actuators A: Physical
SN - 0924-4247
ER -