Abstract
The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis.
| Original language | English |
|---|---|
| Pages (from-to) | 27-37 |
| Number of pages | 11 |
| Journal | Sensors and Actuators, A: Physical |
| Volume | 211 |
| DOIs | |
| Publication status | Published - May 1 2014 |
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All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
Cite this
Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips. / Noda, Toshihiko; Sasagawa, Kiyotaka; Tokuda, Takashi; Terasawa, Yasuo; Tashiro, Hiroyuki; Kanda, Hiroyuki; Fujikado, Takashi; Ohta, Jun.
In: Sensors and Actuators, A: Physical, Vol. 211, 01.05.2014, p. 27-37.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips
AU - Noda, Toshihiko
AU - Sasagawa, Kiyotaka
AU - Tokuda, Takashi
AU - Terasawa, Yasuo
AU - Tashiro, Hiroyuki
AU - Kanda, Hiroyuki
AU - Fujikado, Takashi
AU - Ohta, Jun
PY - 2014/5/1
Y1 - 2014/5/1
N2 - The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis.
AB - The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis.
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U2 - 10.1016/j.sna.2014.03.001
DO - 10.1016/j.sna.2014.03.001
M3 - Article
VL - 211
SP - 27
EP - 37
JO - Sensors and Actuators, A: Physical
JF - Sensors and Actuators, A: Physical
SN - 0924-4247
ER -