Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips

Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuo Terasawa, Hiroyuki Tashiro, Hiroyuki Kanda, Takashi Fujikado, Jun Ohta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis.

Original languageEnglish
Pages (from-to)27-37
Number of pages11
JournalSensors and Actuators, A: Physical
Volume211
DOIs
Publication statusPublished - May 1 2014

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wiring
Iridium
Electric wiring
iridium
CMOS
coatings
Coatings
Electrodes
Oxides
electrodes
oxides
stimuli
miniaturization
durability
Durability
Prostheses and Implants
iridium oxide
experimentation
Electrochemical properties
prototypes

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering

Cite this

Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips. / Noda, Toshihiko; Sasagawa, Kiyotaka; Tokuda, Takashi; Terasawa, Yasuo; Tashiro, Hiroyuki; Kanda, Hiroyuki; Fujikado, Takashi; Ohta, Jun.

In: Sensors and Actuators, A: Physical, Vol. 211, 01.05.2014, p. 27-37.

Research output: Contribution to journalArticle

Noda, Toshihiko ; Sasagawa, Kiyotaka ; Tokuda, Takashi ; Terasawa, Yasuo ; Tashiro, Hiroyuki ; Kanda, Hiroyuki ; Fujikado, Takashi ; Ohta, Jun. / Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips. In: Sensors and Actuators, A: Physical. 2014 ; Vol. 211. pp. 27-37.
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