Performance of an octacalcium phosphate biomaterial in a long bone defect in ovariectomized rat

Kazuyoshi Baba, Yukari Shiwaku, Takahisa Anada, Yu Mori, Kaori Tsuchiya, Eiji Itoi, Osamu Suzuki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: We have reported that octacalcium phosphate (OCP) exhibits direct bone bonding property1 and has in vitro stimulatory capacities on osteoblastic cell differentiation from bone marrow cells not only to osteoblastic cells2,3 but also to late osteocytes4. OCP is also able to enhance formation of osteoclasts from bone marrow cells in the co-presence of osteoblasts5. From these intrinsic mechanisms, OCP is considered to enhance new bone formation coupled with biodegradation6. We hypothesized, therefore, that OCP could be used as a bone substitute material to treat bone defect in pathologic condition such as osteoporotic condition by expressing such cellar stimulatory activities. In the present study, an effect of OCP/gelatin (OCP/Gel) bone substitute material7 on bone formation in a tibial bone defect was investigated using an ovariectomized rat. OCP/Gel has shown to have highly biodegradable characteristics with an immediate bone deposition in a tibial bone defect of a rabbit8. The resorption rate was much higher in OCP/Gel than a high porosity β-tricalcium phosphate (β-TCP).

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Performance of an octacalcium phosphate biomaterial in a long bone defect in ovariectomized rat'. Together they form a unique fingerprint.

Cite this