Pericardial fat pad tissue produces angiogenic factors for healing the bronchial stump

Fumihiro Shojia, Tokujiro Yanoa, Naoko Miuraa, Yosuke Morodomia, Tsukihisa Yoshidaa, Mitsuho Onimarub, Yoshihiko Maeharaa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Maintaining blood flow in and supplying various anti-inflammatory or angiogenic cytokines to the bronchial stump are very important factors involved in its healing. Pericardial fat pad tissue samples surgically obtained from 20 patients were assessed, and their angiogenic ability was investigated. The messenger RNA level of all angiogenic cytokines, including vascular endothelial growth factor, fibroblast growth factor-2 (FGF-2), platelet-derived growth factor-A (PDGF-A), angiopoietin-1 (Ang-1), Ang-2 and hepatocyte growth factor (HGF) were detected in the pericardial fat pad tissue. The protein levels of all cytokines except PDGF-A increased with time from day one to day seven after primary culture of the pericardial fat pad tissue. In particular, both HGF and Ang-2 protein levels on day seven were significantly higher than those on day one (P=0.0475 and P=0.0417, respectively). On the other hand, the protein level of FGF-2 decreased in time and was significantly lower on day seven than on day one (P=0.0296). The present study demonstrated the angiogenic ability of the pericardial fat pad. These results suggest that reinforcement of the bronchial stump by the pericardial fat pad is a worthwhile and justified procedure, and may prevent bronchopleural fistula after pulmonary resections.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalInteractive cardiovascular and thoracic surgery
Volume13
Issue number3
DOIs
Publication statusPublished - Sep 1 2011

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Angiogenesis Inducing Agents
Adipose Tissue
Hepatocyte Growth Factor
Fibroblast Growth Factor 2
Cytokines
Angiopoietin-1
Proteins
Vascular Endothelial Growth Factor A
Fistula
Anti-Inflammatory Agents
Lung
Messenger RNA
platelet-derived growth factor A

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Shojia, F., Yanoa, T., Miuraa, N., Morodomia, Y., Yoshidaa, T., Onimarub, M., & Maeharaa, Y. (2011). Pericardial fat pad tissue produces angiogenic factors for healing the bronchial stump. Interactive cardiovascular and thoracic surgery, 13(3), 271-275. https://doi.org/10.1510/icvts.2011.274480

Pericardial fat pad tissue produces angiogenic factors for healing the bronchial stump. / Shojia, Fumihiro; Yanoa, Tokujiro; Miuraa, Naoko; Morodomia, Yosuke; Yoshidaa, Tsukihisa; Onimarub, Mitsuho; Maeharaa, Yoshihiko.

In: Interactive cardiovascular and thoracic surgery, Vol. 13, No. 3, 01.09.2011, p. 271-275.

Research output: Contribution to journalArticle

Shojia, F, Yanoa, T, Miuraa, N, Morodomia, Y, Yoshidaa, T, Onimarub, M & Maeharaa, Y 2011, 'Pericardial fat pad tissue produces angiogenic factors for healing the bronchial stump', Interactive cardiovascular and thoracic surgery, vol. 13, no. 3, pp. 271-275. https://doi.org/10.1510/icvts.2011.274480
Shojia, Fumihiro ; Yanoa, Tokujiro ; Miuraa, Naoko ; Morodomia, Yosuke ; Yoshidaa, Tsukihisa ; Onimarub, Mitsuho ; Maeharaa, Yoshihiko. / Pericardial fat pad tissue produces angiogenic factors for healing the bronchial stump. In: Interactive cardiovascular and thoracic surgery. 2011 ; Vol. 13, No. 3. pp. 271-275.
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