Abstract
Purpose: The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients. Methods: We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score. Results: Of the 642 patients, 198 (30.8%) received perioperative allogenic blood transfusion (AT group) and 444 (69.2%) did not (non-AT group). Overall survival was lower in the AT group than in the non-AT group in univariate (P < 0.001) and multivariate analyses (risk ratio 1.521, P = 0.011). After matching the different distributions using propensity scores, perioperative blood transfusion was found to be a poor prognostic factor for HCC patients. Conclusions: In this multi-center study, perioperative blood transfusion was an independent factor for poor prognosis after curative surgery for primary HCC in the patient group and in pairs matched by propensity scores.
| Original language | English |
|---|---|
| Pages (from-to) | 73-79 |
| Number of pages | 7 |
| Journal | Surgery Today |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Surgery
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Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery : a multi-center analysis. / Wada, Hiroshi; Eguchi, Hidetoshi; Nagano, Hiroaki; Kubo, Shoji; Nakai, Takuya; Kaibori, Masaki; Hayashi, Michihiro; Takemura, Shigekazu; Tanaka, Shogo; Nakata, Yasuyuki; Matsui, Kosuke; Ishizaki, Morihiko; Hirokawa, Fumitoshi; Komeda, Koji; Uchiyama, Kazuhisa; Kon, Masanori; Doki, Yuichiro; Mori, Masaki.
In: Surgery Today, Vol. 48, No. 1, 01.01.2018, p. 73-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery
T2 - a multi-center analysis
AU - Wada, Hiroshi
AU - Eguchi, Hidetoshi
AU - Nagano, Hiroaki
AU - Kubo, Shoji
AU - Nakai, Takuya
AU - Kaibori, Masaki
AU - Hayashi, Michihiro
AU - Takemura, Shigekazu
AU - Tanaka, Shogo
AU - Nakata, Yasuyuki
AU - Matsui, Kosuke
AU - Ishizaki, Morihiko
AU - Hirokawa, Fumitoshi
AU - Komeda, Koji
AU - Uchiyama, Kazuhisa
AU - Kon, Masanori
AU - Doki, Yuichiro
AU - Mori, Masaki
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose: The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients. Methods: We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score. Results: Of the 642 patients, 198 (30.8%) received perioperative allogenic blood transfusion (AT group) and 444 (69.2%) did not (non-AT group). Overall survival was lower in the AT group than in the non-AT group in univariate (P < 0.001) and multivariate analyses (risk ratio 1.521, P = 0.011). After matching the different distributions using propensity scores, perioperative blood transfusion was found to be a poor prognostic factor for HCC patients. Conclusions: In this multi-center study, perioperative blood transfusion was an independent factor for poor prognosis after curative surgery for primary HCC in the patient group and in pairs matched by propensity scores.
AB - Purpose: The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients. Methods: We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score. Results: Of the 642 patients, 198 (30.8%) received perioperative allogenic blood transfusion (AT group) and 444 (69.2%) did not (non-AT group). Overall survival was lower in the AT group than in the non-AT group in univariate (P < 0.001) and multivariate analyses (risk ratio 1.521, P = 0.011). After matching the different distributions using propensity scores, perioperative blood transfusion was found to be a poor prognostic factor for HCC patients. Conclusions: In this multi-center study, perioperative blood transfusion was an independent factor for poor prognosis after curative surgery for primary HCC in the patient group and in pairs matched by propensity scores.
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UR - http://www.scopus.com/inward/citedby.url?scp=85020419857&partnerID=8YFLogxK
U2 - 10.1007/s00595-017-1553-3
DO - 10.1007/s00595-017-1553-3
M3 - Article
C2 - 28597349
AN - SCOPUS:85020419857
VL - 48
SP - 73
EP - 79
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 1
ER -