Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery

a multi-center analysis

Hiroshi Wada, Hidetoshi Eguchi, Hiroaki Nagano, Shoji Kubo, Takuya Nakai, Masaki Kaibori, Michihiro Hayashi, Shigekazu Takemura, Shogo Tanaka, Yasuyuki Nakata, Kosuke Matsui, Morihiko Ishizaki, Fumitoshi Hirokawa, Koji Komeda, Kazuhisa Uchiyama, Masanori Kon, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients. Methods: We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score. Results: Of the 642 patients, 198 (30.8%) received perioperative allogenic blood transfusion (AT group) and 444 (69.2%) did not (non-AT group). Overall survival was lower in the AT group than in the non-AT group in univariate (P < 0.001) and multivariate analyses (risk ratio 1.521, P = 0.011). After matching the different distributions using propensity scores, perioperative blood transfusion was found to be a poor prognostic factor for HCC patients. Conclusions: In this multi-center study, perioperative blood transfusion was an independent factor for poor prognosis after curative surgery for primary HCC in the patient group and in pairs matched by propensity scores.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalSurgery Today
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

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Blood Transfusion
Hepatocellular Carcinoma
Propensity Score
Hepatectomy
Multivariate Analysis
Odds Ratio
Survival
Liver

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery : a multi-center analysis. / Wada, Hiroshi; Eguchi, Hidetoshi; Nagano, Hiroaki; Kubo, Shoji; Nakai, Takuya; Kaibori, Masaki; Hayashi, Michihiro; Takemura, Shigekazu; Tanaka, Shogo; Nakata, Yasuyuki; Matsui, Kosuke; Ishizaki, Morihiko; Hirokawa, Fumitoshi; Komeda, Koji; Uchiyama, Kazuhisa; Kon, Masanori; Doki, Yuichiro; Mori, Masaki.

In: Surgery Today, Vol. 48, No. 1, 01.01.2018, p. 73-79.

Research output: Contribution to journalArticle

Wada, H, Eguchi, H, Nagano, H, Kubo, S, Nakai, T, Kaibori, M, Hayashi, M, Takemura, S, Tanaka, S, Nakata, Y, Matsui, K, Ishizaki, M, Hirokawa, F, Komeda, K, Uchiyama, K, Kon, M, Doki, Y & Mori, M 2018, 'Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery: a multi-center analysis', Surgery Today, vol. 48, no. 1, pp. 73-79. https://doi.org/10.1007/s00595-017-1553-3
Wada, Hiroshi ; Eguchi, Hidetoshi ; Nagano, Hiroaki ; Kubo, Shoji ; Nakai, Takuya ; Kaibori, Masaki ; Hayashi, Michihiro ; Takemura, Shigekazu ; Tanaka, Shogo ; Nakata, Yasuyuki ; Matsui, Kosuke ; Ishizaki, Morihiko ; Hirokawa, Fumitoshi ; Komeda, Koji ; Uchiyama, Kazuhisa ; Kon, Masanori ; Doki, Yuichiro ; Mori, Masaki. / Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery : a multi-center analysis. In: Surgery Today. 2018 ; Vol. 48, No. 1. pp. 73-79.
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abstract = "Purpose: The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients. Methods: We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score. Results: Of the 642 patients, 198 (30.8{\%}) received perioperative allogenic blood transfusion (AT group) and 444 (69.2{\%}) did not (non-AT group). Overall survival was lower in the AT group than in the non-AT group in univariate (P < 0.001) and multivariate analyses (risk ratio 1.521, P = 0.011). After matching the different distributions using propensity scores, perioperative blood transfusion was found to be a poor prognostic factor for HCC patients. Conclusions: In this multi-center study, perioperative blood transfusion was an independent factor for poor prognosis after curative surgery for primary HCC in the patient group and in pairs matched by propensity scores.",
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AU - Wada, Hiroshi

AU - Eguchi, Hidetoshi

AU - Nagano, Hiroaki

AU - Kubo, Shoji

AU - Nakai, Takuya

AU - Kaibori, Masaki

AU - Hayashi, Michihiro

AU - Takemura, Shigekazu

AU - Tanaka, Shogo

AU - Nakata, Yasuyuki

AU - Matsui, Kosuke

AU - Ishizaki, Morihiko

AU - Hirokawa, Fumitoshi

AU - Komeda, Koji

AU - Uchiyama, Kazuhisa

AU - Kon, Masanori

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2018/1/1

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N2 - Purpose: The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients. Methods: We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score. Results: Of the 642 patients, 198 (30.8%) received perioperative allogenic blood transfusion (AT group) and 444 (69.2%) did not (non-AT group). Overall survival was lower in the AT group than in the non-AT group in univariate (P < 0.001) and multivariate analyses (risk ratio 1.521, P = 0.011). After matching the different distributions using propensity scores, perioperative blood transfusion was found to be a poor prognostic factor for HCC patients. Conclusions: In this multi-center study, perioperative blood transfusion was an independent factor for poor prognosis after curative surgery for primary HCC in the patient group and in pairs matched by propensity scores.

AB - Purpose: The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients. Methods: We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score. Results: Of the 642 patients, 198 (30.8%) received perioperative allogenic blood transfusion (AT group) and 444 (69.2%) did not (non-AT group). Overall survival was lower in the AT group than in the non-AT group in univariate (P < 0.001) and multivariate analyses (risk ratio 1.521, P = 0.011). After matching the different distributions using propensity scores, perioperative blood transfusion was found to be a poor prognostic factor for HCC patients. Conclusions: In this multi-center study, perioperative blood transfusion was an independent factor for poor prognosis after curative surgery for primary HCC in the patient group and in pairs matched by propensity scores.

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