Peripheral b lymphocyte repertoire to mitochondrial antigen in primary biliary cirrhosis - positive correlation between the disease activity and the frequency of circulating b lymphocytes specific for pyruvate dehydroge nase complex

Minoru Nakamura, Hiromi Ishibashi, Mieko Matsui, Shinji Shimoda, Kazuhiro Hayashida, Kichiko Koike, Yoshiyuki Niho

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

B lymphocytes committed to the production of IgG antibodies (Abs) to mitochondrial antigen such as pyruvate dehydrogenase complex(PDC) were quantitated in the peripheral blood of patients with primary biliary cirrhosis(PBC) using Epstein-Barr virus as a polyclonal activator of human B lymphocytes. B lymphocytes committed to the production of IgG Abs to PDC were found in high frequency in patients with PBC(0.54 ± 0.16%, mean value ± SE, of total IgG-producing B lymphocytes) in contrast to type C chronic hepatitis and healthy subjects in which they were less than 0.01%. The frequency of these B lymphocytes specific for PDC increased in parallel to the progression of the Scheuer's stage from I to II(stage 1:0.35 ± 0.23%, stage II: 1.04±0.32%), but decreased with further progression to stage IV(stage III:0.39±0.21%, stageIV:0.07±0.06%). In addition, B lymphocytes specific for PDC decreased in the peripheral blood during the administration of cyclosporin A; this was accompanied by an improvement of lymphocyte infiltration severity in the liver. These data indicate that B lymphocytes specific for PDC are present in the peripheral blood of patients with PBC and their frequency reflects the degree of the lymphocyte infiltration in the liver.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalAutoimmunity
Volume21
Issue number4
DOIs
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Peripheral b lymphocyte repertoire to mitochondrial antigen in primary biliary cirrhosis - positive correlation between the disease activity and the frequency of circulating b lymphocytes specific for pyruvate dehydroge nase complex'. Together they form a unique fingerprint.

Cite this