Peripheral b lymphocyte repertoire to mitochondrial antigen in primary biliary cirrhosis - positive correlation between the disease activity and the frequency of circulating b lymphocytes specific for pyruvate dehydroge nase complex

Minoru Nakamura, Hiromi Ishibashi, Mieko Matsui, Shinji Shimoda, Kazuhiro Hayashida, Kichiko Koike, Yoshiyuki Niho

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

B lymphocytes committed to the production of IgG antibodies (Abs) to mitochondrial antigen such as pyruvate dehydrogenase complex(PDC) were quantitated in the peripheral blood of patients with primary biliary cirrhosis(PBC) using Epstein-Barr virus as a polyclonal activator of human B lymphocytes. B lymphocytes committed to the production of IgG Abs to PDC were found in high frequency in patients with PBC(0.54 ± 0.16%, mean value ± SE, of total IgG-producing B lymphocytes) in contrast to type C chronic hepatitis and healthy subjects in which they were less than 0.01%. The frequency of these B lymphocytes specific for PDC increased in parallel to the progression of the Scheuer's stage from I to II(stage 1:0.35 ± 0.23%, stage II: 1.04±0.32%), but decreased with further progression to stage IV(stage III:0.39±0.21%, stageIV:0.07±0.06%). In addition, B lymphocytes specific for PDC decreased in the peripheral blood during the administration of cyclosporin A; this was accompanied by an improvement of lymphocyte infiltration severity in the liver. These data indicate that B lymphocytes specific for PDC are present in the peripheral blood of patients with PBC and their frequency reflects the degree of the lymphocyte infiltration in the liver.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalAutoimmunity
Volume21
Issue number4
DOIs
Publication statusPublished - Jan 1 1995

Fingerprint

Biliary Liver Cirrhosis
Pyruvic Acid
Pyruvate Dehydrogenase Complex
B-Lymphocytes
Lymphocytes
Antigens
Immunoglobulin G
Antibody Formation
Liver
Chronic Hepatitis C
Human Herpesvirus 4
Cyclosporine
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Peripheral b lymphocyte repertoire to mitochondrial antigen in primary biliary cirrhosis - positive correlation between the disease activity and the frequency of circulating b lymphocytes specific for pyruvate dehydroge nase complex. / Nakamura, Minoru; Ishibashi, Hiromi; Matsui, Mieko; Shimoda, Shinji; Hayashida, Kazuhiro; Koike, Kichiko; Niho, Yoshiyuki.

In: Autoimmunity, Vol. 21, No. 4, 01.01.1995, p. 253-262.

Research output: Contribution to journalArticle

@article{f730651550d34530bd9a1130e504ce4e,
title = "Peripheral b lymphocyte repertoire to mitochondrial antigen in primary biliary cirrhosis - positive correlation between the disease activity and the frequency of circulating b lymphocytes specific for pyruvate dehydroge nase complex",
abstract = "B lymphocytes committed to the production of IgG antibodies (Abs) to mitochondrial antigen such as pyruvate dehydrogenase complex(PDC) were quantitated in the peripheral blood of patients with primary biliary cirrhosis(PBC) using Epstein-Barr virus as a polyclonal activator of human B lymphocytes. B lymphocytes committed to the production of IgG Abs to PDC were found in high frequency in patients with PBC(0.54 ± 0.16{\%}, mean value ± SE, of total IgG-producing B lymphocytes) in contrast to type C chronic hepatitis and healthy subjects in which they were less than 0.01{\%}. The frequency of these B lymphocytes specific for PDC increased in parallel to the progression of the Scheuer's stage from I to II(stage 1:0.35 ± 0.23{\%}, stage II: 1.04±0.32{\%}), but decreased with further progression to stage IV(stage III:0.39±0.21{\%}, stageIV:0.07±0.06{\%}). In addition, B lymphocytes specific for PDC decreased in the peripheral blood during the administration of cyclosporin A; this was accompanied by an improvement of lymphocyte infiltration severity in the liver. These data indicate that B lymphocytes specific for PDC are present in the peripheral blood of patients with PBC and their frequency reflects the degree of the lymphocyte infiltration in the liver.",
author = "Minoru Nakamura and Hiromi Ishibashi and Mieko Matsui and Shinji Shimoda and Kazuhiro Hayashida and Kichiko Koike and Yoshiyuki Niho",
year = "1995",
month = "1",
day = "1",
doi = "10.3109/08916939509001944",
language = "English",
volume = "21",
pages = "253--262",
journal = "Autoimmunity",
issn = "0891-6934",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Peripheral b lymphocyte repertoire to mitochondrial antigen in primary biliary cirrhosis - positive correlation between the disease activity and the frequency of circulating b lymphocytes specific for pyruvate dehydroge nase complex

AU - Nakamura, Minoru

AU - Ishibashi, Hiromi

AU - Matsui, Mieko

AU - Shimoda, Shinji

AU - Hayashida, Kazuhiro

AU - Koike, Kichiko

AU - Niho, Yoshiyuki

PY - 1995/1/1

Y1 - 1995/1/1

N2 - B lymphocytes committed to the production of IgG antibodies (Abs) to mitochondrial antigen such as pyruvate dehydrogenase complex(PDC) were quantitated in the peripheral blood of patients with primary biliary cirrhosis(PBC) using Epstein-Barr virus as a polyclonal activator of human B lymphocytes. B lymphocytes committed to the production of IgG Abs to PDC were found in high frequency in patients with PBC(0.54 ± 0.16%, mean value ± SE, of total IgG-producing B lymphocytes) in contrast to type C chronic hepatitis and healthy subjects in which they were less than 0.01%. The frequency of these B lymphocytes specific for PDC increased in parallel to the progression of the Scheuer's stage from I to II(stage 1:0.35 ± 0.23%, stage II: 1.04±0.32%), but decreased with further progression to stage IV(stage III:0.39±0.21%, stageIV:0.07±0.06%). In addition, B lymphocytes specific for PDC decreased in the peripheral blood during the administration of cyclosporin A; this was accompanied by an improvement of lymphocyte infiltration severity in the liver. These data indicate that B lymphocytes specific for PDC are present in the peripheral blood of patients with PBC and their frequency reflects the degree of the lymphocyte infiltration in the liver.

AB - B lymphocytes committed to the production of IgG antibodies (Abs) to mitochondrial antigen such as pyruvate dehydrogenase complex(PDC) were quantitated in the peripheral blood of patients with primary biliary cirrhosis(PBC) using Epstein-Barr virus as a polyclonal activator of human B lymphocytes. B lymphocytes committed to the production of IgG Abs to PDC were found in high frequency in patients with PBC(0.54 ± 0.16%, mean value ± SE, of total IgG-producing B lymphocytes) in contrast to type C chronic hepatitis and healthy subjects in which they were less than 0.01%. The frequency of these B lymphocytes specific for PDC increased in parallel to the progression of the Scheuer's stage from I to II(stage 1:0.35 ± 0.23%, stage II: 1.04±0.32%), but decreased with further progression to stage IV(stage III:0.39±0.21%, stageIV:0.07±0.06%). In addition, B lymphocytes specific for PDC decreased in the peripheral blood during the administration of cyclosporin A; this was accompanied by an improvement of lymphocyte infiltration severity in the liver. These data indicate that B lymphocytes specific for PDC are present in the peripheral blood of patients with PBC and their frequency reflects the degree of the lymphocyte infiltration in the liver.

UR - http://www.scopus.com/inward/record.url?scp=0029583075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029583075&partnerID=8YFLogxK

U2 - 10.3109/08916939509001944

DO - 10.3109/08916939509001944

M3 - Article

C2 - 8852516

AN - SCOPUS:0029583075

VL - 21

SP - 253

EP - 262

JO - Autoimmunity

JF - Autoimmunity

SN - 0891-6934

IS - 4

ER -