Peripheral blood stem cell transplantation - Current status and issues -

Katsuto Takenaka, M. Harada

Research output: Contribution to journalArticle

Abstract

Autologous peripheral blood stem celt transplantation (auto-PBSCT) has been increasingly used in the treatment of malignant disease, and has begun to replace autologous bone marrow transplantation (autoBMT) because of rapid engraftment and low transplant-related mortality. Some clinical studies have demonstrated the safety and efficacy of high-dose chemotherapy followed by auto-PBSCT for the treatment of acute myelogenous leukemia, malignant lymphoma, multiple myeloma, and solid tumor such as breast cancer. Recently, allogeneic PBSCT (allo-PBSCT) s being evaluated as an alternative to alloBMT. Recent studies suggest that allo-PBSCT results in more rapid engraftment without an apparent increase in acute graft-versus-host disease (aGVHD) as compared to bone marrow, but further studies will be required to assess its efficacy.

Original languageEnglish
Pages (from-to)360-369
Number of pages10
JournalBiotherapy
Volume12
Issue number3
Publication statusPublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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