Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion

Katsuhisa Miyake, Masafumi Moriyama, Kumiko Aizawa, Shuji Nagano, Yasushi Inoue, Atsushi Sadanaga, Hitoshi Nakashima, Seiji Nakamura

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjögren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalModern Rheumatology
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 1 2008

All Science Journal Classification (ASJC) codes

  • Rheumatology

Fingerprint Dive into the research topics of 'Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion'. Together they form a unique fingerprint.

  • Cite this