Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion

Katsuhisa Miyake, Masafumi Moriyama, Kumiko Aizawa, Shuji Nagano, Yasushi Inoue, Atsushi Sadanaga, Hitoshi Nakashima, Seiji Nakamura

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjögren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalModern Rheumatology
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 1 2008

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Mikulicz' Disease
Pleural Effusion
Th1-Th2 Balance
T-Lymphocytes
Phenotype
Submandibular Gland
Prednisolone
Salivary Glands
Immunoglobulin G
Lymph Nodes
Lymphadenopathy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Rheumatology

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Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion. / Miyake, Katsuhisa; Moriyama, Masafumi; Aizawa, Kumiko; Nagano, Shuji; Inoue, Yasushi; Sadanaga, Atsushi; Nakashima, Hitoshi; Nakamura, Seiji.

In: Modern Rheumatology, Vol. 18, No. 1, 01.02.2008, p. 86-90.

Research output: Contribution to journalArticle

Miyake, Katsuhisa ; Moriyama, Masafumi ; Aizawa, Kumiko ; Nagano, Shuji ; Inoue, Yasushi ; Sadanaga, Atsushi ; Nakashima, Hitoshi ; Nakamura, Seiji. / Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion. In: Modern Rheumatology. 2008 ; Vol. 18, No. 1. pp. 86-90.
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