Peripheral choriovitreal neovascularization in proliferative diabetic retinopathy: Histopathologic and ultrastructural study

Tatsuro Ishibashi, Toshinori Murata, Toshihiko Kohno, Yoshitaka Ohnishi, Hajime Inomata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We describe the histopathologic and ultrastructural evidence of choriovitreal neovascularization in the peripheral fundus of a non- vitrectomized eye with proliferative diabetic retinopathy (PDR). One eye with PDR was surgically enucleated because of neovascular glaucoma and studied with light and electron microscopy. The eye had neovascular membranes at the ora serrata of the peripheral fundus. The newly formed vessels originated from the choroid, passed through Bruch's membrane and the retina, and extended into the vitreous. These vessels had either developing or mature characteristics. The endothelial cells of the developing vessels contained a bulky cytoplasm with many intracytoplasmic filaments, ribosomes and rough endoplasmic reticulum. Budding endothelial cells were frequently found in the developing vessels. The endothelial cells of the mature vessels had attenuated cytoplasm and fenestrations with diaphragms. These observations suggest that choriovitreal neovascularization in the peripheral fundus is one of the features of PDR.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalOphthalmologica
Volume213
Issue number3
DOIs
Publication statusPublished - Jan 1 1999

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems

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