Peripheral clock gene expression in CS mice with bimodal locomotor rhythms

Tsuyoshi Watanabe, Mayumi Kojima, Shigeru Tomida, Takahiro J. Nakamura, Takashi Yamamura, Nobuhiro Nakao, Shinobu Yasuo, Takashi Yoshimura, Shizufumi Ebihara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

CS mice show unique properties of circadian rhythms: unstable free-running periods and distinct bimodal rhythms (similar to rhythm splitting, but hereafter referred to as bimodal rhythms) under constant darkness. In the present study, we compared clock-related gene expression (mPer1, mBmal1 and Dbp) in the SCN and peripheral tissues (liver, adrenal gland and heart) between CS and C57BL/6J mice. In spite of normal robust oscillation in the SCN of both mice, behavioral rhythms and peripheral rhythms of clock-related genes were significantly different between these mice. However, when daytime restricted feeding was given, no essential differences between the two strains were observed. These results indicate that unusual circadian behaviors and peripheral gene expression in CS mice do not depend on the SCN but rather mechanisms outside of the SCN.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalNeuroscience Research
Volume54
Issue number4
DOIs
Publication statusPublished - Apr 1 2006

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Gene Expression
Darkness
Adrenal Glands
Circadian Rhythm
Inbred C57BL Mouse
Liver
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Watanabe, T., Kojima, M., Tomida, S., Nakamura, T. J., Yamamura, T., Nakao, N., ... Ebihara, S. (2006). Peripheral clock gene expression in CS mice with bimodal locomotor rhythms. Neuroscience Research, 54(4), 295-301. https://doi.org/10.1016/j.neures.2005.12.009

Peripheral clock gene expression in CS mice with bimodal locomotor rhythms. / Watanabe, Tsuyoshi; Kojima, Mayumi; Tomida, Shigeru; Nakamura, Takahiro J.; Yamamura, Takashi; Nakao, Nobuhiro; Yasuo, Shinobu; Yoshimura, Takashi; Ebihara, Shizufumi.

In: Neuroscience Research, Vol. 54, No. 4, 01.04.2006, p. 295-301.

Research output: Contribution to journalArticle

Watanabe, T, Kojima, M, Tomida, S, Nakamura, TJ, Yamamura, T, Nakao, N, Yasuo, S, Yoshimura, T & Ebihara, S 2006, 'Peripheral clock gene expression in CS mice with bimodal locomotor rhythms', Neuroscience Research, vol. 54, no. 4, pp. 295-301. https://doi.org/10.1016/j.neures.2005.12.009
Watanabe T, Kojima M, Tomida S, Nakamura TJ, Yamamura T, Nakao N et al. Peripheral clock gene expression in CS mice with bimodal locomotor rhythms. Neuroscience Research. 2006 Apr 1;54(4):295-301. https://doi.org/10.1016/j.neures.2005.12.009
Watanabe, Tsuyoshi ; Kojima, Mayumi ; Tomida, Shigeru ; Nakamura, Takahiro J. ; Yamamura, Takashi ; Nakao, Nobuhiro ; Yasuo, Shinobu ; Yoshimura, Takashi ; Ebihara, Shizufumi. / Peripheral clock gene expression in CS mice with bimodal locomotor rhythms. In: Neuroscience Research. 2006 ; Vol. 54, No. 4. pp. 295-301.
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