Peritoneal adherent cells inhibit the generation of cytotoxic T lymphocytes with prostaglandin-mediated system

Yasuhiro Koga, Kazuto Taniguchi, Chiharu Kubo, Kikuo Nomoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Responder spleen cells primed to alloantigens in vivo could generate high degree of cytotoxicity against low- or nonimmunogenic stimulators such as thymocytes or uv light-treated spleen cells in vitro. However, a removal of adherent cells from primed responder cells remarkably reduced the cytotoxicity after stimulation with such low-immunogenic stimulators. Adding a small number of peritoneal adherent cells (PACs) also suppressed the cytotoxic activity of unseparated responders against low-immunogenic stimulators. These suppressive effects by PACs were blocked by indomethacin. By adding prostaglandin E2, cytotoxic T lymphocyte (CTL) generation of primed unseparated responders against low-immunogenic stimulators was suppressed; however, cytotoxic activity against mitomycin C-treated stimulators was not suppressed. These results suggested that prostaglandins released from PACs selectively inhibited the function of splenic adherent cells that were required for CTL generation of primed responder spleen cells against low-immunogenic stimulators in vitro.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalCellular Immunology
Volume66
Issue number1
DOIs
Publication statusPublished - Jan 1 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology

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