Peritumoral Hyperintensity at Hepatobiliary Phase Gadoxetic Acid–enhanced MRI in Hepatic Neuroendocrine Tumors

Nobuhiro Fujita, Atsuhiko Handa, Jinha M. Park

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background/Aim: To identify the imaging and clinical features of hepatic neuroendocrine tumors (NETs) associated with peritumoral hyperintensity in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance (MR) imaging. Patients and Methods: Fifty-seven patients with hepatic NETs were enrolled. Based on the degree of peritumoral hyperintensity, patients were divided into three groups: group 0 (no peritumoral hyperintensity), group 1 (lower peritumoral hyperintensity), and group 2 (higher peritumoral hyperintensity). The imaging and clinical findings were compared among the three groups. Results: Apparent diffusion coefficient (ADC) values of group 2 were significantly lower than those of group 0 and group 1. Atypical (cholangiocarcinoma-like) enhancement pattern in the arterial phase was significantly more frequently observed in group 2 as compared to that in group 0 and group 1. Group 2 patients showed significantly poorer progression-free survival than group 0 patients. Conclusion: Hepatic NETs with greater peritumoral hyperintensity exhibit greater malignant potential.

Original languageEnglish
Pages (from-to)911-917
Number of pages7
JournalAnticancer research
Volume42
Issue number2
DOIs
Publication statusPublished - Feb 2022

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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