Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: Implications for obsessive-compulsive disorder

Michihiko Matsushita, Nobuaki Egashira, Satoko Harada, Ryoko Okuno, Kenichi Mishima, Katsunori Iwasaki, Ryoji Nishimura, Michihiro Fujiwara

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Perospirone is a novel atypical antipsychotic drug with dopamine (DA) D2- and serotonin (5-hydroxytryptamine, 5-HT) 5-HT 2A-receptor antagonist, and 5-HT1A-receptor agonist properties. In the present study, we examined the effect of perospirone on marble-burying behavior, which has been considered an animal model of obsessive-compulsive disorder (OCD), compared with the effects of other antipsychotics such as haloperidol and risperidone. Perospirone at a dose of 10 mg/kg (p.o.) inhibited marble-burying behavior without affecting the locomotor activity in mice. On the other hand, haloperidol (0.1 mg/kg, i.p.) and risperidone (1 mg/kg, p.o.) showed significant suppression of locomotor activity at the dose that inhibited marble-burying behavior. Furthermore, the inhibition of marble-burying behavior by perospirone was antagonized by WAY100135 (10 mg/kg, i.p.), a selective 5-HT1A-receptor antagonist. WAY100135 at the same dose also antagonized the inhibition of marble-burying behavior by 8-OH-DPAT (3 mg/kg, i.p.), a selective 5-HT1A-receptor agonist. These findings suggest that perospirone may exhibit anti-OCD activity in clinical use and that 5-HT1A-receptor agonistic activity may be involved in the inhibition of marble-burying behavior by perospirone.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
JournalJournal of Pharmacological Sciences
Volume99
Issue number2
DOIs
Publication statusPublished - Nov 7 2005
Externally publishedYes

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Receptor, Serotonin, 5-HT1A
Calcium Carbonate
Obsessive-Compulsive Disorder
Antipsychotic Agents
Serotonin 5-HT1 Receptor Agonists
Risperidone
Haloperidol
Locomotion
Serotonin
Serotonin 5-HT1 Receptor Antagonists
8-Hydroxy-2-(di-n-propylamino)tetralin
Serotonin Receptors
perospirone
Dopamine
Animal Models
Inhibition (Psychology)

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice : Implications for obsessive-compulsive disorder. / Matsushita, Michihiko; Egashira, Nobuaki; Harada, Satoko; Okuno, Ryoko; Mishima, Kenichi; Iwasaki, Katsunori; Nishimura, Ryoji; Fujiwara, Michihiro.

In: Journal of Pharmacological Sciences, Vol. 99, No. 2, 07.11.2005, p. 154-159.

Research output: Contribution to journalArticle

Matsushita, Michihiko ; Egashira, Nobuaki ; Harada, Satoko ; Okuno, Ryoko ; Mishima, Kenichi ; Iwasaki, Katsunori ; Nishimura, Ryoji ; Fujiwara, Michihiro. / Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice : Implications for obsessive-compulsive disorder. In: Journal of Pharmacological Sciences. 2005 ; Vol. 99, No. 2. pp. 154-159.
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