Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma

Fumiyoshi Fushimi, Kenichi Taguchi, Hiroto Izumi, Kimitoshi Kohno, Michihiko Kuwano, Mayumi Ono, Yutaka Nakashima, Tetsuro Takesue, Seiji Naito, Yoshinao Oda

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Patients with end-stage renal disease are exposed to increased oxidative stress and impairment of antioxidant mechanisms. We focused on dialysis renal cell carcinoma (RCC), including epithelial hyperplasia in acquired cystic disease of the kidney (ACDK). We attempted to obtain insight into the carcinogenesis and tumor progression in terms of cellular defense mechanisms associated with oxidative stress by investigating the expression of antioxidant proteins by immunohistochemistry. We evaluated retrospectively 43 cases of dialysis RCC and, as a control group, 49 cases of sporadic RCC. Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. In epithelial hyperplasia, in 17 cases of acquired cystic disease of the kidney, Prxs and thioredoxin were highly expressed. Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. In dialysis RCC, Prx 3, 4, and 5 immunoreactivity positively correlated with the Fuhrman nuclear grade. These data suggest that oxidative stress during dialysis enhances antioxidant activity, with an inhibiting effect on carcinogenesis. Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC.

Original languageEnglish
Pages (from-to)553-562
Number of pages10
JournalVirchows Archiv
Volume463
Issue number4
DOIs
Publication statusPublished - Oct 1 2013

Fingerprint

Y-Box-Binding Protein 1
Peroxiredoxins
Thioredoxins
Renal Cell Carcinoma
Dialysis
Peroxiredoxin III
Antioxidants
Cystic Kidney Diseases
Oxidative Stress
Hyperplasia
Carcinogenesis
Chronic Kidney Failure
Neoplasms
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma. / Fushimi, Fumiyoshi; Taguchi, Kenichi; Izumi, Hiroto; Kohno, Kimitoshi; Kuwano, Michihiko; Ono, Mayumi; Nakashima, Yutaka; Takesue, Tetsuro; Naito, Seiji; Oda, Yoshinao.

In: Virchows Archiv, Vol. 463, No. 4, 01.10.2013, p. 553-562.

Research output: Contribution to journalArticle

Fushimi, Fumiyoshi ; Taguchi, Kenichi ; Izumi, Hiroto ; Kohno, Kimitoshi ; Kuwano, Michihiko ; Ono, Mayumi ; Nakashima, Yutaka ; Takesue, Tetsuro ; Naito, Seiji ; Oda, Yoshinao. / Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma. In: Virchows Archiv. 2013 ; Vol. 463, No. 4. pp. 553-562.
@article{360c99dd0749403ab0db4a34c5c265e2,
title = "Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma",
abstract = "Patients with end-stage renal disease are exposed to increased oxidative stress and impairment of antioxidant mechanisms. We focused on dialysis renal cell carcinoma (RCC), including epithelial hyperplasia in acquired cystic disease of the kidney (ACDK). We attempted to obtain insight into the carcinogenesis and tumor progression in terms of cellular defense mechanisms associated with oxidative stress by investigating the expression of antioxidant proteins by immunohistochemistry. We evaluated retrospectively 43 cases of dialysis RCC and, as a control group, 49 cases of sporadic RCC. Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. In epithelial hyperplasia, in 17 cases of acquired cystic disease of the kidney, Prxs and thioredoxin were highly expressed. Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. In dialysis RCC, Prx 3, 4, and 5 immunoreactivity positively correlated with the Fuhrman nuclear grade. These data suggest that oxidative stress during dialysis enhances antioxidant activity, with an inhibiting effect on carcinogenesis. Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC.",
author = "Fumiyoshi Fushimi and Kenichi Taguchi and Hiroto Izumi and Kimitoshi Kohno and Michihiko Kuwano and Mayumi Ono and Yutaka Nakashima and Tetsuro Takesue and Seiji Naito and Yoshinao Oda",
year = "2013",
month = "10",
day = "1",
doi = "10.1007/s00428-013-1460-y",
language = "English",
volume = "463",
pages = "553--562",
journal = "Virchows Archiv",
issn = "0945-6317",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma

AU - Fushimi, Fumiyoshi

AU - Taguchi, Kenichi

AU - Izumi, Hiroto

AU - Kohno, Kimitoshi

AU - Kuwano, Michihiko

AU - Ono, Mayumi

AU - Nakashima, Yutaka

AU - Takesue, Tetsuro

AU - Naito, Seiji

AU - Oda, Yoshinao

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Patients with end-stage renal disease are exposed to increased oxidative stress and impairment of antioxidant mechanisms. We focused on dialysis renal cell carcinoma (RCC), including epithelial hyperplasia in acquired cystic disease of the kidney (ACDK). We attempted to obtain insight into the carcinogenesis and tumor progression in terms of cellular defense mechanisms associated with oxidative stress by investigating the expression of antioxidant proteins by immunohistochemistry. We evaluated retrospectively 43 cases of dialysis RCC and, as a control group, 49 cases of sporadic RCC. Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. In epithelial hyperplasia, in 17 cases of acquired cystic disease of the kidney, Prxs and thioredoxin were highly expressed. Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. In dialysis RCC, Prx 3, 4, and 5 immunoreactivity positively correlated with the Fuhrman nuclear grade. These data suggest that oxidative stress during dialysis enhances antioxidant activity, with an inhibiting effect on carcinogenesis. Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC.

AB - Patients with end-stage renal disease are exposed to increased oxidative stress and impairment of antioxidant mechanisms. We focused on dialysis renal cell carcinoma (RCC), including epithelial hyperplasia in acquired cystic disease of the kidney (ACDK). We attempted to obtain insight into the carcinogenesis and tumor progression in terms of cellular defense mechanisms associated with oxidative stress by investigating the expression of antioxidant proteins by immunohistochemistry. We evaluated retrospectively 43 cases of dialysis RCC and, as a control group, 49 cases of sporadic RCC. Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. In epithelial hyperplasia, in 17 cases of acquired cystic disease of the kidney, Prxs and thioredoxin were highly expressed. Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. In dialysis RCC, Prx 3, 4, and 5 immunoreactivity positively correlated with the Fuhrman nuclear grade. These data suggest that oxidative stress during dialysis enhances antioxidant activity, with an inhibiting effect on carcinogenesis. Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC.

UR - http://www.scopus.com/inward/record.url?scp=84885587301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885587301&partnerID=8YFLogxK

U2 - 10.1007/s00428-013-1460-y

DO - 10.1007/s00428-013-1460-y

M3 - Article

VL - 463

SP - 553

EP - 562

JO - Virchows Archiv

JF - Virchows Archiv

SN - 0945-6317

IS - 4

ER -