TY - CHAP
T1 - Peroxisome
T2 - Metabolic Functions and Biogenesis
AU - Okumoto, Kanji
AU - Tamura, Shigehiko
AU - Honsho, Masanori
AU - Fujiki, Yukio
N1 - Funding Information:
Acknowledgements We apologize to the colleagues in this field for not citing all their work due to space limitations. This work was supported in part by Grants-in-Aid for Scientific Research: JP24770130 (to K.O.), JP24570134 (to S.T.), JP26440102 and JP17K07337 (to M.H.), and JP24247038, JP25112518, JP25116717, JP 26116007, JP15K14511, JP15K21743, and JP117H03675 (to Y.F.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, a CREST grant (to Y.F.) from the Science and Technology Agency of Japan, and grants (to Y.F.) from the Takeda Science Foundation, the Naito Foundation, and Japan Foundation for Applied Enzymology.
Publisher Copyright:
© 2020, Springer Nature Switzerland AG.
PY - 2020
Y1 - 2020
N2 - Peroxisome is an organelle conserved in almost all eukaryotic cells with a variety of functions in cellular metabolism, including fatty acid β-oxidation, synthesis of ether glycerolipid plasmalogens, and redox homeostasis. Such metabolic functions and the exclusive importance of peroxisomes have been highlighted in fatal human genetic disease called peroxisomal biogenesis disorders (PBDs). Recent advances in this field have identified over 30 PEX genes encoding peroxins as essential factors for peroxisome biogenesis in various species from yeast to humans. Functional delineation of the peroxins has revealed that peroxisome biogenesis comprises the processes, involving peroxisomal membrane assembly, matrix protein import, division, and proliferation. Catalase, the most abundant peroxisomal enzyme, catalyzes decomposition of hydrogen peroxide. Peroxisome plays pivotal roles in the cellular redox homeostasis and the response to oxidative stresses, depending on intracellular localization of catalase.
AB - Peroxisome is an organelle conserved in almost all eukaryotic cells with a variety of functions in cellular metabolism, including fatty acid β-oxidation, synthesis of ether glycerolipid plasmalogens, and redox homeostasis. Such metabolic functions and the exclusive importance of peroxisomes have been highlighted in fatal human genetic disease called peroxisomal biogenesis disorders (PBDs). Recent advances in this field have identified over 30 PEX genes encoding peroxins as essential factors for peroxisome biogenesis in various species from yeast to humans. Functional delineation of the peroxins has revealed that peroxisome biogenesis comprises the processes, involving peroxisomal membrane assembly, matrix protein import, division, and proliferation. Catalase, the most abundant peroxisomal enzyme, catalyzes decomposition of hydrogen peroxide. Peroxisome plays pivotal roles in the cellular redox homeostasis and the response to oxidative stresses, depending on intracellular localization of catalase.
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U2 - 10.1007/978-3-030-60204-8_1
DO - 10.1007/978-3-030-60204-8_1
M3 - Chapter
C2 - 33417203
AN - SCOPUS:85099688126
T3 - Advances in Experimental Medicine and Biology
SP - 3
EP - 17
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
