Persistent depression is a significant risk factor for the development of arteriosclerosis in middle-aged Japanese male subjects

Depression often coexists with hypertension and various cardiovascular diseases. However, the relationship between depression and the development of arteriosclerosis has not been fully established. We assessed depression and brachial-ankle pulse wave velocity (baPWV) in 828 middle-aged Japanese male subjects at baseline and during 3 years of follow-up. Depression was assessed using Center for Epidemiological Studies-Depression questionnaires, and the study subjects were divided into the following three groups: persistent depression, transient depression and no depression. The number (%) of subjects with persistent, transient and no depression were 104 (12.6), 76 (9.2) and 648 (78.2), respectively. Blood pressure and baPWV did not differ among the three groups at baseline. The changes in the baPWV values (baPWV) correlated significantly and positively with age, body mass index, baseline systolic blood pressure and persistent depression (r=0.32, P<0.01). After 3 years of follow-up, the baPWV was significantly greater in subjects with persistent depression compared with those with no depression (36±28 vs. 18±10 cm s^-1, P=0.02). After adjustment for conventional risk factors, persistent depression was significantly associated with baPWV by multiple regression analysis (β=0.261, P<0.01). To sum up, persistent depression was a significant risk factor for the development of arteriosclerosis in middle-aged Japanese male subjects.