Persistent diffusion abnormalities in the brain stem of three children with mitochondrial diseases

Y. Sakai, Ryutaro Kira, H. Torisu, K. Ihara, T. Yoshiura, T. Hara

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

We report 2 children (patients 1 and 2) with Kearns-Sayre syndrome and 1 (patient 3) with Leigh syndrome, who underwent serial diffusion-weighted MR imaging (DWI) studies for 2.8 (patient 1), 4.2 (patient 2), and 1.0 years (patient 3). The DWI revealed the persistent hyperintense signals in the pontine and mesencephalic tegmenta. The apparent diffusion coefficient in the affected regions remained constantly low, suggesting that cytotoxic edema and spongiform degenerations may compose these brain stem lesions.

Original languageEnglish
Pages (from-to)1924-1926
Number of pages3
JournalAmerican Journal of Neuroradiology
Volume27
Issue number9
Publication statusPublished - Oct 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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