Persistent hypertension does not alter the cerebral blood flow and glucose utilization in young-adult Dahl salt-sensitive rats

Tetsujiro Yasuda, Junya Shigematsu, Shozo Tobimatsu, Shosuke Takahashi, Motohiro Kato

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Abstract

The Dahl-Iwai salt-sensitive (DS) rat develops hypertension due to a high-salt diet without any structural alterations of the brain arteries and arterioles. We investigated the effect of persistent hypertension on the regional cerebral blood flow (rCBF) and regional cerebral glucose utilization (rCGU) in the DS rats. The rats were fed either a high-salt diet (HSD; 8% NaCl, n=5) or a low-salt diet (LSD; 0.3% NaCl, n=6) from 8 to 16 weeks of age, and the HSD group developed hypertension lasting for 1 month. At 16 weeks of age, the rCBF was measured in the sensorimotor and visual cortices using the hydrogen clearance method, and the rCGU was measured in 26 different brain structures using the [14C]deoxyglucose method. The mean arterial pressure was significantly higher in the HSD group (168±7 mm Hg) than in the LSD group (139±3 mm Hg) (P<0.01). The mean rCBF and the rCGU values tended to be lower in the HSD group than in the LSD group; however, there were no statistically significant differences except for the reduced rCGU value in the nucleus accumbens. These results suggest that hypertension itself does not alter either the rCBF or the rCGU in young-adult DS rats. This indicates that the functional/structural changes of the cerebral arteries and arterioles that are associated with hypertension appear to be responsible for altered rCBF and rCGU in other animal models of hypertension.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalJournal of the Neurological Sciences
Volume197
Issue number1-2
DOIs
Publication statusPublished - May 15 2002

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Cerebrovascular Circulation
Inbred Dahl Rats
Regional Blood Flow
Blood Glucose
Young Adult
Hypertension
Glucose
Lysergic Acid Diethylamide
Arterioles
Salts
Diet
Sodium-Restricted Diet
Cerebral Arteries
Deoxyglucose
Nucleus Accumbens
Brain
Visual Cortex
Hydrogen
Arterial Pressure
Animal Models

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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Persistent hypertension does not alter the cerebral blood flow and glucose utilization in young-adult Dahl salt-sensitive rats. / Yasuda, Tetsujiro; Shigematsu, Junya; Tobimatsu, Shozo; Takahashi, Shosuke; Kato, Motohiro.

In: Journal of the Neurological Sciences, Vol. 197, No. 1-2, 15.05.2002, p. 19-26.

Research output: Contribution to journalArticle

Yasuda, Tetsujiro ; Shigematsu, Junya ; Tobimatsu, Shozo ; Takahashi, Shosuke ; Kato, Motohiro. / Persistent hypertension does not alter the cerebral blood flow and glucose utilization in young-adult Dahl salt-sensitive rats. In: Journal of the Neurological Sciences. 2002 ; Vol. 197, No. 1-2. pp. 19-26.
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