Persistent T-cell mixed chimerism in a case of malignant lymphoma after nonmyeloablative allogeneic peripheral blood stem cell transplantation

Eriko Nagasawa, Yasunobu Abe, Takamitsu Matsushima, Ilseung Choi, Yoshimichi Tachikawa, Junji Nishimura, Shoichi Inaba, Hajime Nawata, Koichiro Muta

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a 51-year-old woman with recurrent follicular lymphoma from the age of 47 despite chemo-radio therapy, who subsequently underwent nonmyeloablative stem cell transplantation with conditioning consisting of fludarabine and low-dose total body irradiation (2 Gy). Myelosuppression was very mild, so the patient required no transfusions. Chimerism analysis from peripheral blood showed that T-cell mixed chimerism continued over 12 months after stem cell transplantation (the percentage of recipient T-cells was approximately 20%). Despite this, the lymphadenopathy disappeared, and the patient developed grade II acute GVHD (graft versus host disease). It has been considered that the establishment of full donor chimerism is required to induce GVHD and GVM (graft versus malignancy) effects. In this case, however, an allo-response was observed despite the persistence of T-cell mixed chimerism.

Original languageEnglish
Pages (from-to)1014-1019
Number of pages6
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume43
Issue number11
Publication statusPublished - Nov 2002

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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