Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses

Isao Ito, Daisuke Okada, Hiroyuki Sugiyama

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalNeuroscience Letters
Volume90
Issue number1-2
DOIs
Publication statusPublished - Jul 19 1988
Externally publishedYes

Fingerprint

Hippocampal Mossy Fibers
Long-Term Potentiation
Pertussis Toxin
Synapses
Intraventricular Injections
Pyramidal Cells
Bovine Serum Albumin
GTP-Binding Proteins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses. / Ito, Isao; Okada, Daisuke; Sugiyama, Hiroyuki.

In: Neuroscience Letters, Vol. 90, No. 1-2, 19.07.1988, p. 181-185.

Research output: Contribution to journalArticle

Ito, Isao ; Okada, Daisuke ; Sugiyama, Hiroyuki. / Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses. In: Neuroscience Letters. 1988 ; Vol. 90, No. 1-2. pp. 181-185.
@article{4285a48b7ead46a996c9ed896d4e3f2b,
title = "Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses",
abstract = "The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.",
author = "Isao Ito and Daisuke Okada and Hiroyuki Sugiyama",
year = "1988",
month = "7",
day = "19",
doi = "10.1016/0304-3940(88)90808-7",
language = "English",
volume = "90",
pages = "181--185",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses

AU - Ito, Isao

AU - Okada, Daisuke

AU - Sugiyama, Hiroyuki

PY - 1988/7/19

Y1 - 1988/7/19

N2 - The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.

AB - The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.

UR - http://www.scopus.com/inward/record.url?scp=0023907869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023907869&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(88)90808-7

DO - 10.1016/0304-3940(88)90808-7

M3 - Article

C2 - 3412640

AN - SCOPUS:0023907869

VL - 90

SP - 181

EP - 185

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -