Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses

Isao Ito, Daisuke Okada, Hiroyuki Sugiyama

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalNeuroscience Letters
Volume90
Issue number1-2
DOIs
Publication statusPublished - Jul 19 1988

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses'. Together they form a unique fingerprint.

Cite this