PET evaluation of cerebral hemodynamics in occlusive cerebrovascular disease pre- and postsurgery

Yasuo Kuwabara, Yuichi Ichiya, Masayuki Sasaki, Tsuyoshi Yoshida, Toshimitsu Fukumura, Kouji Masuda, Kiyotaka Fujii, Masashi Fukui

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Abstract

We studied cerebral blood flow (CBF), oxygen extraction fraction (OEF), transit time (TT) and hemodynamic reserve capacity using acetazolamide (ACZ) in both the pre- and postoperative states, and evaluated the effect of surgery on the cerebral hemodynamics. Methods: Twelve patients with a unilateral occlusive cerebral artery were studied. Among them, seven patients had extracranial-intracranial (EC-IC) bypass surgery, while the remaining five patients had carotid endarterectomies. The CBF was measured using the 15O-water bolus injection method in a resting state, 5 and 20 min after intravenous ACZ (1 g), while the OEF and TT were measured by the 15O steady state method. The values of these parameters were obtained by regions of interest set over the cerebral hemisphere on both sides, and which then were compared between the pre- and postoperative states using the paired Student's t-test. Results: The t values were 1.36 (CBF at rest), 2.97 (CBF at 5 min after intravenous ACZ), 1.40 (CBF at 20 min after intravenous ACZ), 2.00 (OEF) and -0.86 (TT) on the surgical side, and -0.16, 0.21, 0.22, -0.47 and 0.61 on the nonsurgical side, respectively. The t values of the ACZ response (% increase in CBF) were 3.07 (5 min after intravenous ACZ) and 0.72 (20 min) on the surgical side, and 1.03 and 0.90 on the nonsurgical side, respectively. A significant change was observed only in the CBF studies 5 min after intravenous ACZ. Conclusion: PET can demonstrate significant cerebral hemodynamic change after surgery, especially in CBF measurement 5 min after intravenous ACZ, and may therefore be useful for evaluating cerebral hemodynamics pre- and postsurgery.

Original languageEnglish
Pages (from-to)760-765
Number of pages6
JournalJournal of Nuclear Medicine
Volume39
Issue number5
Publication statusPublished - May 1 1998

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Cerebrovascular Circulation
Cerebrovascular Disorders
Acetazolamide
Hemodynamics
Oxygen
Cerebral Arteries
Carotid Endarterectomy
Cerebrum
Students

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kuwabara, Y., Ichiya, Y., Sasaki, M., Yoshida, T., Fukumura, T., Masuda, K., ... Fukui, M. (1998). PET evaluation of cerebral hemodynamics in occlusive cerebrovascular disease pre- and postsurgery. Journal of Nuclear Medicine, 39(5), 760-765.

PET evaluation of cerebral hemodynamics in occlusive cerebrovascular disease pre- and postsurgery. / Kuwabara, Yasuo; Ichiya, Yuichi; Sasaki, Masayuki; Yoshida, Tsuyoshi; Fukumura, Toshimitsu; Masuda, Kouji; Fujii, Kiyotaka; Fukui, Masashi.

In: Journal of Nuclear Medicine, Vol. 39, No. 5, 01.05.1998, p. 760-765.

Research output: Contribution to journalArticle

Kuwabara, Y, Ichiya, Y, Sasaki, M, Yoshida, T, Fukumura, T, Masuda, K, Fujii, K & Fukui, M 1998, 'PET evaluation of cerebral hemodynamics in occlusive cerebrovascular disease pre- and postsurgery', Journal of Nuclear Medicine, vol. 39, no. 5, pp. 760-765.
Kuwabara Y, Ichiya Y, Sasaki M, Yoshida T, Fukumura T, Masuda K et al. PET evaluation of cerebral hemodynamics in occlusive cerebrovascular disease pre- and postsurgery. Journal of Nuclear Medicine. 1998 May 1;39(5):760-765.
Kuwabara, Yasuo ; Ichiya, Yuichi ; Sasaki, Masayuki ; Yoshida, Tsuyoshi ; Fukumura, Toshimitsu ; Masuda, Kouji ; Fujii, Kiyotaka ; Fukui, Masashi. / PET evaluation of cerebral hemodynamics in occlusive cerebrovascular disease pre- and postsurgery. In: Journal of Nuclear Medicine. 1998 ; Vol. 39, No. 5. pp. 760-765.
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abstract = "We studied cerebral blood flow (CBF), oxygen extraction fraction (OEF), transit time (TT) and hemodynamic reserve capacity using acetazolamide (ACZ) in both the pre- and postoperative states, and evaluated the effect of surgery on the cerebral hemodynamics. Methods: Twelve patients with a unilateral occlusive cerebral artery were studied. Among them, seven patients had extracranial-intracranial (EC-IC) bypass surgery, while the remaining five patients had carotid endarterectomies. The CBF was measured using the 15O-water bolus injection method in a resting state, 5 and 20 min after intravenous ACZ (1 g), while the OEF and TT were measured by the 15O steady state method. The values of these parameters were obtained by regions of interest set over the cerebral hemisphere on both sides, and which then were compared between the pre- and postoperative states using the paired Student's t-test. Results: The t values were 1.36 (CBF at rest), 2.97 (CBF at 5 min after intravenous ACZ), 1.40 (CBF at 20 min after intravenous ACZ), 2.00 (OEF) and -0.86 (TT) on the surgical side, and -0.16, 0.21, 0.22, -0.47 and 0.61 on the nonsurgical side, respectively. The t values of the ACZ response ({\%} increase in CBF) were 3.07 (5 min after intravenous ACZ) and 0.72 (20 min) on the surgical side, and 1.03 and 0.90 on the nonsurgical side, respectively. A significant change was observed only in the CBF studies 5 min after intravenous ACZ. Conclusion: PET can demonstrate significant cerebral hemodynamic change after surgery, especially in CBF measurement 5 min after intravenous ACZ, and may therefore be useful for evaluating cerebral hemodynamics pre- and postsurgery.",
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