pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

Tomomi Koshiyama, Yuki Inoue, Sana Asada, Koki Kawahara, Shogo Ide, Kazuma Yasuhara, Masaaki Ohba

Research output: Contribution to journalArticlepeer-review

Abstract

Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ion permeability with a selective response to Cu2+ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.

Original languageEnglish
Pages (from-to)2895-2898
Number of pages4
JournalChemical Communications
Volume57
Issue number23
DOIs
Publication statusPublished - Mar 21 2021

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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