pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

Tomomi Koshiyama; Yuki Inoue; Sana Asada; Koki Kawahara; Shogo Ide; Kazuma Yasuhara; Masaaki Ohba

doi:10.1039/d0cc08368b

pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

Tomomi Koshiyama, Yuki Inoue, Sana Asada, Koki Kawahara, Shogo Ide, Kazuma Yasuhara, Masaaki Ohba

Inorganic and Analytical Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca²⁺ion permeability with a selective response to Cu²⁺ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.

Original language	English
Pages (from-to)	2895-2898
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	23
DOIs	https://doi.org/10.1039/d0cc08368b
Publication status	Published - Mar 21 2021

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d0cc08368b

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title = "pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation",

abstract = "Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ion permeability with a selective response to Cu2+ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.",

author = "Tomomi Koshiyama and Yuki Inoue and Sana Asada and Koki Kawahara and Shogo Ide and Kazuma Yasuhara and Masaaki Ohba",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}{\textquoteleft}Chemistry for Multimolecular Crowding Biosystems{\textquoteright}{\textquoteright} (JSPS KAKENHI Grant No. 20H04718) to T. K., and {\textquoteleft}{\textquoteleft}Coordination Asymmetry{\textquoteright}{\textquoteright} (JSPS KAKENHI Grant No. 16H06519) to M. O. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

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day = "21",

doi = "10.1039/d0cc08368b",

language = "English",

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T1 - pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

AU - Koshiyama, Tomomi

AU - Inoue, Yuki

AU - Asada, Sana

AU - Kawahara, Koki

AU - Ide, Shogo

AU - Yasuhara, Kazuma

AU - Ohba, Masaaki

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas ‘‘Chemistry for Multimolecular Crowding Biosystems’’ (JSPS KAKENHI Grant No. 20H04718) to T. K., and ‘‘Coordination Asymmetry’’ (JSPS KAKENHI Grant No. 16H06519) to M. O. Publisher Copyright: © The Royal Society of Chemistry 2021.

PY - 2021/3/21

Y1 - 2021/3/21

N2 - Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ion permeability with a selective response to Cu2+ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.

AB - Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ion permeability with a selective response to Cu2+ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.

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JO - Chemical Communications

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pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

Abstract

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