Abstract
The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.
Original language | English |
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Pages (from-to) | 529-532 |
Number of pages | 4 |
Journal | Soft Matter |
Volume | 5 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2009 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Condensed Matter Physics