PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

Akihiro Kishimura, Sittipong Liamsuwan, Hiroyuki Matsuda, Wen Fei Dong, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalSoft Matter
Volume5
Issue number3
DOIs
Publication statusPublished - Jul 13 2009

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Dynamic light scattering
Microscopic examination
permeability
Membranes
Scanning
Lasers
compartments
delivery
vehicles
light scattering
membranes
microscopy
scanning
sensitivity
lasers

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

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PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media. / Kishimura, Akihiro; Liamsuwan, Sittipong; Matsuda, Hiroyuki; Dong, Wen Fei; Osada, Kensuke; Yamasaki, Yuichi; Kataoka, Kazunori.

In: Soft Matter, Vol. 5, No. 3, 13.07.2009, p. 529-532.

Research output: Contribution to journalArticle

Kishimura, Akihiro ; Liamsuwan, Sittipong ; Matsuda, Hiroyuki ; Dong, Wen Fei ; Osada, Kensuke ; Yamasaki, Yuichi ; Kataoka, Kazunori. / PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media. In: Soft Matter. 2009 ; Vol. 5, No. 3. pp. 529-532.
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