PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

Akihiro Kishimura, Sittipong Liamsuwan, Hiroyuki Matsuda, Wen Fei Dong, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalSoft Matter
Volume5
Issue number3
DOIs
Publication statusPublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media'. Together they form a unique fingerprint.

Cite this