PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

Akihiro Kishimura; Sittipong Liamsuwan; Hiroyuki Matsuda; Wen Fei Dong; Kensuke Osada; Yuichi Yamasaki; Kazunori Kataoka

doi:10.1039/b815884c

PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

Akihiro Kishimura, Sittipong Liamsuwan, Hiroyuki Matsuda, Wen Fei Dong, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.

Original language	English
Pages (from-to)	529-532
Number of pages	4
Journal	Soft Matter
Volume	5
Issue number	3
DOIs	https://doi.org/10.1039/b815884c
Publication status	Published - 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry(all)
Condensed Matter Physics

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PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media. / Kishimura, Akihiro; Liamsuwan, Sittipong; Matsuda, Hiroyuki; Dong, Wen Fei; Osada, Kensuke; Yamasaki, Yuichi; Kataoka, Kazunori.

In: Soft Matter, Vol. 5, No. 3, 2009, p. 529-532.

Research output: Contribution to journal › Article › peer-review

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AU - Dong, Wen Fei

AU - Osada, Kensuke

AU - Yamasaki, Yuichi

AU - Kataoka, Kazunori

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PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

Abstract

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