Abstract
The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.
| Original language | English |
|---|---|
| Pages (from-to) | 529-532 |
| Number of pages | 4 |
| Journal | Soft Matter |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 13 2009 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Condensed Matter Physics
Cite this
PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media. / Kishimura, Akihiro; Liamsuwan, Sittipong; Matsuda, Hiroyuki; Dong, Wen Fei; Osada, Kensuke; Yamasaki, Yuichi; Kataoka, Kazunori.
In: Soft Matter, Vol. 5, No. 3, 13.07.2009, p. 529-532.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media
AU - Kishimura, Akihiro
AU - Liamsuwan, Sittipong
AU - Matsuda, Hiroyuki
AU - Dong, Wen Fei
AU - Osada, Kensuke
AU - Yamasaki, Yuichi
AU - Kataoka, Kazunori
PY - 2009/7/13
Y1 - 2009/7/13
N2 - The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.
AB - The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.
UR - http://www.scopus.com/inward/record.url?scp=66649098260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66649098260&partnerID=8YFLogxK
U2 - 10.1039/b815884c
DO - 10.1039/b815884c
M3 - Article
AN - SCOPUS:66649098260
VL - 5
SP - 529
EP - 532
JO - Soft Matter
JF - Soft Matter
SN - 1744-683X
IS - 3
ER -