Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring.

Tiejiao Zhang, Yosuke Tachiya, Yuichi Sakaguchi, Katsuhiko Mitsumoto, Tatsuya Mitsumoto, Nobuyoshi Ohya, Masayuki Sasaki

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7 Citations (Scopus)

Abstract

The aim of this study was to determine an appropriate threshold value for delineation of the target volume in PET/CT and to investigate whether we could delineate a target volume by phantom studies. A phantom consisted of six spheres (phi 10-37 mm) filled with 18F solution. Data acquisition was performed PET/CT in non-motion and motion status with high 18F solution and in non-motion status with low 18F solution. In non-motion phantom experiments, we determined two types of threshold value, an absolute SUV (T(SUV)) and a percentage of the maximum SUV (T%). Delineation using threshold values was applied for all spheres and for selected large spheres (a diameter of 22 mm or larger). In motion phantom experiments, data acquisition was performed in a static mode (sPET) and a gated mode (gPET). CT scanning was performed with helical CT (HCT) and 4-dimensional CT (4DCT). The appropriate threshold values were aT% = 27% and aT(SUV) = 2.4 for all spheres, and sT% = 30% and sT(SUV) = 4.3 for selected spheres. For all spheres in sPET/HCT in motion, the delineated volumes were 84%-129% by the aT% and 34%-127% by the aT(SUV). In gPET/4DCT in motion, the delineated volumes were 94-103% by the aT% and 51-131% by the aT(SUV). For low radioactivity spheres, the delineated volumes were all underestimated. A threshold value of T% = 27% was proposed for auto-contouring of lung tumors. Our results also suggested that the respiratory gated data acquisition should be performed in both PET and CT for target volume delineation.

Original languageEnglish
Pages (from-to)238-246
Number of pages9
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume101
Issue number11
Publication statusPublished - Nov 1 2010

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Spiral Computed Tomography
Cone-Beam Computed Tomography
Radioactivity
Lung
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Zhang, T., Tachiya, Y., Sakaguchi, Y., Mitsumoto, K., Mitsumoto, T., Ohya, N., & Sasaki, M. (2010). Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring. Fukuoka igaku zasshi = Hukuoka acta medica, 101(11), 238-246.

Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring. / Zhang, Tiejiao; Tachiya, Yosuke; Sakaguchi, Yuichi; Mitsumoto, Katsuhiko; Mitsumoto, Tatsuya; Ohya, Nobuyoshi; Sasaki, Masayuki.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 101, No. 11, 01.11.2010, p. 238-246.

Research output: Contribution to journalArticle

Zhang, T, Tachiya, Y, Sakaguchi, Y, Mitsumoto, K, Mitsumoto, T, Ohya, N & Sasaki, M 2010, 'Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring.', Fukuoka igaku zasshi = Hukuoka acta medica, vol. 101, no. 11, pp. 238-246.
Zhang T, Tachiya Y, Sakaguchi Y, Mitsumoto K, Mitsumoto T, Ohya N et al. Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring. Fukuoka igaku zasshi = Hukuoka acta medica. 2010 Nov 1;101(11):238-246.
Zhang, Tiejiao ; Tachiya, Yosuke ; Sakaguchi, Yuichi ; Mitsumoto, Katsuhiko ; Mitsumoto, Tatsuya ; Ohya, Nobuyoshi ; Sasaki, Masayuki. / Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring. In: Fukuoka igaku zasshi = Hukuoka acta medica. 2010 ; Vol. 101, No. 11. pp. 238-246.
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