Abstract
We evaluated the acute toxicity of some pharmaceuticals and personal care products (PPCPs) to the survival of Japanese medaka (Oryzias latipes). Adult medaka were exposed to different concentrations of triclosan (TCS; 1, 2, 2.4 and 3mg/L), diclofenac (DCF; 9,12,15 and 18mg/L) or carbamazepine (CBMZ; 60, 65, 70, 90 and 100 mg/L) for 96 h in a semi-static water exposure system. In order of decreasing toxicity to medaka, the 96-h LC 50 values were TCS, 1.7 mg/L; DCF, 10.1 mg/L; and CBMZ, 61.5 mg/L. We compared the no observed effect concentration (NOEC) determined from this study with the predicted environmental concentrations (PEC) and concluded that TCS and DCF pose potential risks to medaka but the risk from CBMZ is negligible.
| Original language | English |
|---|---|
| Pages (from-to) | 407-411 |
| Number of pages | 5 |
| Journal | Journal of the Faculty of Agriculture, Kyushu University |
| Volume | 54 |
| Issue number | 2 |
| Publication status | Published - Oct 1 2009 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Agronomy and Crop Science
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Pharmaceuticals and personal care products toxicity to Japanese medaka fish (Oryzias latipes). / Nassef, Mohamed; Matsumoto, Shuhei; Seki, Masanori; Kang, Ik Joon; Moroishi, Junya; Shimasaki, Yohei; Oshima, Yuji.
In: Journal of the Faculty of Agriculture, Kyushu University, Vol. 54, No. 2, 01.10.2009, p. 407-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmaceuticals and personal care products toxicity to Japanese medaka fish (Oryzias latipes)
AU - Nassef, Mohamed
AU - Matsumoto, Shuhei
AU - Seki, Masanori
AU - Kang, Ik Joon
AU - Moroishi, Junya
AU - Shimasaki, Yohei
AU - Oshima, Yuji
PY - 2009/10/1
Y1 - 2009/10/1
N2 - We evaluated the acute toxicity of some pharmaceuticals and personal care products (PPCPs) to the survival of Japanese medaka (Oryzias latipes). Adult medaka were exposed to different concentrations of triclosan (TCS; 1, 2, 2.4 and 3mg/L), diclofenac (DCF; 9,12,15 and 18mg/L) or carbamazepine (CBMZ; 60, 65, 70, 90 and 100 mg/L) for 96 h in a semi-static water exposure system. In order of decreasing toxicity to medaka, the 96-h LC 50 values were TCS, 1.7 mg/L; DCF, 10.1 mg/L; and CBMZ, 61.5 mg/L. We compared the no observed effect concentration (NOEC) determined from this study with the predicted environmental concentrations (PEC) and concluded that TCS and DCF pose potential risks to medaka but the risk from CBMZ is negligible.
AB - We evaluated the acute toxicity of some pharmaceuticals and personal care products (PPCPs) to the survival of Japanese medaka (Oryzias latipes). Adult medaka were exposed to different concentrations of triclosan (TCS; 1, 2, 2.4 and 3mg/L), diclofenac (DCF; 9,12,15 and 18mg/L) or carbamazepine (CBMZ; 60, 65, 70, 90 and 100 mg/L) for 96 h in a semi-static water exposure system. In order of decreasing toxicity to medaka, the 96-h LC 50 values were TCS, 1.7 mg/L; DCF, 10.1 mg/L; and CBMZ, 61.5 mg/L. We compared the no observed effect concentration (NOEC) determined from this study with the predicted environmental concentrations (PEC) and concluded that TCS and DCF pose potential risks to medaka but the risk from CBMZ is negligible.
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M3 - Article
AN - SCOPUS:70450158564
VL - 54
SP - 407
EP - 411
JO - Journal of the Faculty of Agriculture, Kyushu University
JF - Journal of the Faculty of Agriculture, Kyushu University
SN - 0023-6152
IS - 2
ER -