Abstract
Nonlinear mixed effects modeling was used to estimate the effects of digoxin-calcium channel blockers (verapamil, diltiazem, nifedipine) in 336 serum levels gathered from 172 patients (104 male and 68 female) receiving oral digoxin as hospital in-patients. The final model describing digoxin clearance (CL) was CL where Ccr is the estimated creatinine clearance (ml/min); CCB=1 for concomitant administration of calcium channel blockers and CCB = zero otherwise; CHF = 1 for the patients with congestive heart failure and CHF = zero otherwise; SPI = 1 for concomitant administration of spironolactone and SPI = zero otherwise; DFAC = 1 for administration of a half-tablet of digoxin and DFAC = zero otherwise. Concomitant administration of calcium channel blockers resulted in a 13% decrease in digoxin relative clearance.
Original language | English |
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Pages (from-to) | 173-181 |
Number of pages | 9 |
Journal | Biopharmaceutics and Drug Disposition |
Volume | 23 |
Issue number | 5 |
DOIs | |
Publication status | Published - Jul 2002 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmaceutical Science
- Pharmacology (medical)