Pharmacogenomics: Inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs

Ichiro Ieiri, Shun Higuchi

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Intra- and inter-ethnic diferences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs are important issues not only for scenes of appropriate drug use in clinical settings but also for those of the drug development. Pharmacogenomics is extremely useful for understanding these racial differences. In this presentation, I will introduce pharmacogenomic concepts (e.g., single nucleotide polymorphisms (SNPs) and haplotype) for interpretation of racial differences in some drugs; pharmacogenomics of drug transporters such as OATP1B1 (organic anion transporting-polypeptide 1B1) and OCT1 (organic cation transporter 1) in pravastatin, metformin, and rosuvastatin will be discussed as model drugs.

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalYakugaku Zasshi
Volume129
Issue number2
DOIs
Publication statusPublished - Feb 1 2009

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Pharmacogenetics
Pharmacokinetics
Pharmaceutical Preparations
Organic Cation Transporter 1
Pravastatin
Metformin
Haplotypes
Single Nucleotide Polymorphism
Anions
Peptides

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Pharmacogenomics : Inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs. / Ieiri, Ichiro; Higuchi, Shun.

In: Yakugaku Zasshi, Vol. 129, No. 2, 01.02.2009, p. 231-235.

Research output: Contribution to journalReview article

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