Pharmacokinetic analysis based on dynamic contrast-enhanced MRI for evaluating tumor response to preoperative therapy for oral cancer

Toru Chikui, Erina Kitamoto, Shintarou Kawano, Tsuyoshi Sugiura, Makoto Obara, Arjan W. Simonetti, Masamitsu Hatakenaka, Yoshio Matsuo, Shoichi Koga, Masahiro Ohga, Katsumasa Nakamura, Kazunori Yoshiura

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Purpose: To evaluate whether a pharmacokinetic analysis is useful for monitoring the response of oral cancer to chemoradiotherapy (CRT). Materials and Methods: Twenty-nine patients were included. They underwent dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) before and after CRT. The DCE-MRI data were analyzed using a Tofts and Kermode (TK) model. The histological evaluation of the effects of CRT was performed according to Ohboshi and Shimosato's classification. Results: None of the pre-CRT parameters were significantly different between the responders and nonresponders. The post-CRT volume of the extravascular extracellular space (EES) per unit volume of tissue (ve) of responders (0.397 ± 0.080) was higher than that of nonresponders (0.281 ± 0.076) (P = 0.01). The change of the ve between the pre- and post-CRT of the responders (0.154 ± 0.093) was larger than that of the nonresponders (0.033 ± 0.073) (P = 0.001). Therefore, the increase in the ve strongly suggested a good tumor response to CRT, which reflected an increase of the EES secondary to the destruction of the cancer nest. The changes in the volume transfer constant (Ktrans) were significantly different between the responders and nonresponders (P = 0.018). Conclusion: Both the increase of the ve and the elevation of permeability (Ktrans) were indicative of a good tumor response to CRT. The pharmacokinetic analysis had potential for monitoring the histopathological response to CRT. J. Magn. Reson. Imaging 2012;36:589-597.

Original languageEnglish
Pages (from-to)589-597
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume36
Issue number3
DOIs
Publication statusPublished - Sep 1 2012

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Mouth Neoplasms
Chemoradiotherapy
Pharmacokinetics
Neoplasms
Therapeutics
Extracellular Space
Magnetic Resonance Imaging
Permeability

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Pharmacokinetic analysis based on dynamic contrast-enhanced MRI for evaluating tumor response to preoperative therapy for oral cancer. / Chikui, Toru; Kitamoto, Erina; Kawano, Shintarou; Sugiura, Tsuyoshi; Obara, Makoto; Simonetti, Arjan W.; Hatakenaka, Masamitsu; Matsuo, Yoshio; Koga, Shoichi; Ohga, Masahiro; Nakamura, Katsumasa; Yoshiura, Kazunori.

In: Journal of Magnetic Resonance Imaging, Vol. 36, No. 3, 01.09.2012, p. 589-597.

Research output: Contribution to journalArticle

Chikui, Toru ; Kitamoto, Erina ; Kawano, Shintarou ; Sugiura, Tsuyoshi ; Obara, Makoto ; Simonetti, Arjan W. ; Hatakenaka, Masamitsu ; Matsuo, Yoshio ; Koga, Shoichi ; Ohga, Masahiro ; Nakamura, Katsumasa ; Yoshiura, Kazunori. / Pharmacokinetic analysis based on dynamic contrast-enhanced MRI for evaluating tumor response to preoperative therapy for oral cancer. In: Journal of Magnetic Resonance Imaging. 2012 ; Vol. 36, No. 3. pp. 589-597.
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AU - Obara, Makoto

AU - Simonetti, Arjan W.

AU - Hatakenaka, Masamitsu

AU - Matsuo, Yoshio

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AB - Purpose: To evaluate whether a pharmacokinetic analysis is useful for monitoring the response of oral cancer to chemoradiotherapy (CRT). Materials and Methods: Twenty-nine patients were included. They underwent dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) before and after CRT. The DCE-MRI data were analyzed using a Tofts and Kermode (TK) model. The histological evaluation of the effects of CRT was performed according to Ohboshi and Shimosato's classification. Results: None of the pre-CRT parameters were significantly different between the responders and nonresponders. The post-CRT volume of the extravascular extracellular space (EES) per unit volume of tissue (ve) of responders (0.397 ± 0.080) was higher than that of nonresponders (0.281 ± 0.076) (P = 0.01). The change of the ve between the pre- and post-CRT of the responders (0.154 ± 0.093) was larger than that of the nonresponders (0.033 ± 0.073) (P = 0.001). Therefore, the increase in the ve strongly suggested a good tumor response to CRT, which reflected an increase of the EES secondary to the destruction of the cancer nest. The changes in the volume transfer constant (Ktrans) were significantly different between the responders and nonresponders (P = 0.018). Conclusion: Both the increase of the ve and the elevation of permeability (Ktrans) were indicative of a good tumor response to CRT. The pharmacokinetic analysis had potential for monitoring the histopathological response to CRT. J. Magn. Reson. Imaging 2012;36:589-597.

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