Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism

Suttasinee Suwannakul, Ichiro Ieiri, Miyuki Kimura, Kiyoshi Kawabata, Hiroyuki Kusuhara, Takeshi Hirota, Shin Irie, Yuichi Sugiyama, Shun Higuchi

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30 Citations (Scopus)

Abstract

The impact of SLCO1B1 polymorphism on the pharmacokinetics of olmesartan and on the pharmacokinetic interaction between pravastatin and olmesartan was investigated. On day 1, ten healthy volunteers took an oral dose (10 mg) of pravastatin. After a 3-day washout period, each subject received olmesartan medoxomil (10 mg) for 3 days. On day 8, they received olmesartan medoxomil (10 mg) and pravastatin (10 mg) concurrently, and pharmacokinetic profiles were compared with those in each single-dose phase with regard to the SLCO1B1 genotypes (*1b/*1b,*1b/*15, and*15/*15). In the single-dose phase, the mean C max and AUC0-24 of olmesartan tended to be higher in *15/*15 subjects than in *1b/*1b subjects, while the mean CL t /F (±SD) in *15/*15 subjects was significantly lower than that in *1b/*1b subjects. No statistically significant differences were observed in any pharmacokinetic parameters between single-dose and co-administration phases for both pravastatin and RMS-416. These results suggest that OATP1B1 plays a role in the pharmacokinetics of olmesartan, and the co-administration of olmesartan does not affect the pharmacokinetics of pravastatin or its metabolite, RMS-416, although larger scale clinical studies are needed to confirm these observations due to the small sample size in the present study.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalJournal of Human Genetics
Volume53
Issue number10
DOIs
Publication statusPublished - Oct 1 2008

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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