We conducted pharmacokinetic studies after oral administration of 250 mg metformin to reexamine its dose-setting in Japan, where the maximum dose is limited to 750 mg daily. T max was 4 hrs in healthy controls(n=6) and diabetic patients(n=5). C max was 0.54±0.15 μg/ml in control and 0.85±0.19 μg/ml in diabetic patients, consistent with data reported in the English literature. In repetitive administration of 500 mg metformin daily for 7 days, serum concentration of metformin reached the steady state on day 3, and the profile of metformin concentration on day 7 fitted well with the concentration curve predicted by that on day 1. No significant differences were seen in T max, C max, or T 1/2 on days 1 and 7. We report the pharmacokinetics of metformin at the dose set in Japan.
|Number of pages||5|
|Journal||Journal of the Japan Diabetes Society|
|Publication status||Published - 2004|
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism