Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

Toshio Hisatomi; Tatsuro Ishibashi; Joan W. Miller; Guido Kroemer

doi:10.1016/j.expneurol.2009.03.007

Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

Toshio Hisatomi, Tatsuro Ishibashi, Joan W. Miller, Guido Kroemer

Kyushu University Hospital

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the "point of no return" of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.

Original language	English
Pages (from-to)	347-352
Number of pages	6
Journal	Experimental Neurology
Volume	218
Issue number	2
DOIs	https://doi.org/10.1016/j.expneurol.2009.03.007
Publication status	Published - Aug 2009

All Science Journal Classification (ASJC) codes

Neurology
Developmental Neuroscience

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10.1016/j.expneurol.2009.03.007

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title = "Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection",

abstract = "Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the {"}point of no return{"} of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.",

author = "Toshio Hisatomi and Tatsuro Ishibashi and Miller, {Joan W.} and Guido Kroemer",

note = "Funding Information: GK is supported by the Ligue Nationale contre le Cancer (Equipe labellis{\'e}e), European Commission (Active p53, Apo-Sys, RIGHT, TransDeath, ChemoRes, DeathTrain), Canc{\'e}rop{\^o}le Ile-de-France, Fondation de France, and Fondation pour la Recherche M{\'e}dicale.",

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AU - Hisatomi, Toshio

AU - Ishibashi, Tatsuro

AU - Miller, Joan W.

AU - Kroemer, Guido

N1 - Funding Information: GK is supported by the Ligue Nationale contre le Cancer (Equipe labellisée), European Commission (Active p53, Apo-Sys, RIGHT, TransDeath, ChemoRes, DeathTrain), Cancéropôle Ile-de-France, Fondation de France, and Fondation pour la Recherche Médicale.

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N2 - Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the "point of no return" of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.

AB - Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the "point of no return" of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.

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Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

Abstract

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