Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

Toshio Hisatomi, Tatsuro Ishibashi, Joan W. Miller, Guido Kroemer

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the "point of no return" of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalExperimental Neurology
Volume218
Issue number2
DOIs
Publication statusPublished - Aug 1 2009

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

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