Quisqualate- and kainate-preferring glutamate receptors were studied in Xenopus oocytes injected with rat and chick brain mRNA. All ligands effective at ionotropic quisqualate sites, agonists as well as antagonists, were found to inhibit kainate responses. Ionotropic quisqualate and kainate responses were distinguished by γ-l-glutamylglycine but not by its d-isomer. No difference was detected between responses induced by rat brain mRNA and chick brain mRNA, suggesting that the properties on non-N-methyl-d-aspartate-type glutamate receptors of rat and chick brains are essentially the same.
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