Pharmacological properties of quisqualate- and kainate-preferring glutamate receptors induced in Xenopus oocytes by rat and chick brain mRNA

H. Sugiyama; M. Watanabe; H. Taji; Y. Yamamoto; I. Ito

doi:10.1016/0168-0102(89)90057-6

Pharmacological properties of quisqualate- and kainate-preferring glutamate receptors induced in Xenopus oocytes by rat and chick brain mRNA

H. Sugiyama, M. Watanabe, H. Taji, Y. Yamamoto, I. Ito

Biology, Faculty of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Quisqualate- and kainate-preferring glutamate receptors were studied in Xenopus oocytes injected with rat and chick brain mRNA. All ligands effective at ionotropic quisqualate sites, agonists as well as antagonists, were found to inhibit kainate responses. Ionotropic quisqualate and kainate responses were distinguished by γ-l-glutamylglycine but not by its d-isomer. No difference was detected between responses induced by rat brain mRNA and chick brain mRNA, suggesting that the properties on non-N-methyl-d-aspartate-type glutamate receptors of rat and chick brains are essentially the same.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Neuroscience Research
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/0168-0102(89)90057-6
Publication status	Published - Nov 1989

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/0168-0102(89)90057-6

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title = "Pharmacological properties of quisqualate- and kainate-preferring glutamate receptors induced in Xenopus oocytes by rat and chick brain mRNA",

abstract = "Quisqualate- and kainate-preferring glutamate receptors were studied in Xenopus oocytes injected with rat and chick brain mRNA. All ligands effective at ionotropic quisqualate sites, agonists as well as antagonists, were found to inhibit kainate responses. Ionotropic quisqualate and kainate responses were distinguished by γ-l-glutamylglycine but not by its d-isomer. No difference was detected between responses induced by rat brain mRNA and chick brain mRNA, suggesting that the properties on non-N-methyl-d-aspartate-type glutamate receptors of rat and chick brains are essentially the same.",

author = "H. Sugiyama and M. Watanabe and H. Taji and Y. Yamamoto and I. Ito",

note = "Funding Information: This study was supportedin part by grantsf rom the JapaneseM inistryof Education, Science and Culture (Nos. 63112002,6 3638002,6 3641538,6 3480110,0 1641541a nd 01659517)a, nd from the Brain ScienceF oundationJ,a pan.",

year = "1989",

month = nov,

doi = "10.1016/0168-0102(89)90057-6",

language = "English",

volume = "7",

pages = "164--167",

journal = "Neuroscience Research",

issn = "0168-0102",

publisher = "Elsevier Ireland Ltd",

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T1 - Pharmacological properties of quisqualate- and kainate-preferring glutamate receptors induced in Xenopus oocytes by rat and chick brain mRNA

AU - Sugiyama, H.

AU - Watanabe, M.

AU - Taji, H.

AU - Yamamoto, Y.

AU - Ito, I.

N1 - Funding Information: This study was supportedin part by grantsf rom the JapaneseM inistryof Education, Science and Culture (Nos. 63112002,6 3638002,6 3641538,6 3480110,0 1641541a nd 01659517)a, nd from the Brain ScienceF oundationJ,a pan.

PY - 1989/11

Y1 - 1989/11

N2 - Quisqualate- and kainate-preferring glutamate receptors were studied in Xenopus oocytes injected with rat and chick brain mRNA. All ligands effective at ionotropic quisqualate sites, agonists as well as antagonists, were found to inhibit kainate responses. Ionotropic quisqualate and kainate responses were distinguished by γ-l-glutamylglycine but not by its d-isomer. No difference was detected between responses induced by rat brain mRNA and chick brain mRNA, suggesting that the properties on non-N-methyl-d-aspartate-type glutamate receptors of rat and chick brains are essentially the same.

AB - Quisqualate- and kainate-preferring glutamate receptors were studied in Xenopus oocytes injected with rat and chick brain mRNA. All ligands effective at ionotropic quisqualate sites, agonists as well as antagonists, were found to inhibit kainate responses. Ionotropic quisqualate and kainate responses were distinguished by γ-l-glutamylglycine but not by its d-isomer. No difference was detected between responses induced by rat brain mRNA and chick brain mRNA, suggesting that the properties on non-N-methyl-d-aspartate-type glutamate receptors of rat and chick brains are essentially the same.

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Pharmacological properties of quisqualate- and kainate-preferring glutamate receptors induced in Xenopus oocytes by rat and chick brain mRNA

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