Pharmacologically regulated induction of silent mutations (PRISM): Combined pharmacological and genetic approaches for learning and memory

Paul W. Frankland, Masuo Ohno, Eiki Takahashi, Adele R. Chen, Rui M. Costa, Steven A. Kushner, Alcino J. Silva

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Mouse transgenic and knock-out approaches have made fundamental contributions to our understanding of the molecular and cellular bases of learning and memory. These approaches have successfully identified a large number of molecules with either a central or modulatory role in learning and memory. However, there are limitations associated with first-generation mutant mice, which include, for example, the lack of temporal control over the mutation. Recent technical developments have started to address some of these shortcomings. Here, the authors review a newly developed inducible approach that takes advantage of synergistic interactions between subthreshold genetic and pharmacological manipulations. This approach is easily set up and can be used to study the functional interactions between molecules in signaling pathways.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalNeuroscientist
Volume9
Issue number2
DOIs
Publication statusPublished - Apr 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

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