Abstract
Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of CIPO patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric CIPO in Japan. Methods: In 2012, a nationwide survey was conducted to identify the clinical presentation of CIPO in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: “probiotics”, “Japanese herbal medicines (Kampo medicines)”, “laxatives”, and “prokinetics”. Results: Ninety-two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty-four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70% of whom were treated specifically with mosapride. Conclusion: Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat CIPO in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric CIPO in Japan.
| Original language | English |
|---|---|
| Pages (from-to) | 467-472 |
| Number of pages | 6 |
| Journal | Pediatrics International |
| Volume | 59 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2017 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
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Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction : Nationwide survey in Japan. / Hashizume, Naoki; Yagi, Minoru; Ushijima, Kosuke; Seki, Yoshitaka; Fukahori, Suguru; Muto, Mitsuru; Matsufuji, Hiroshi; Taguchi, Tomoaki.
In: Pediatrics International, Vol. 59, No. 4, 01.04.2017, p. 467-472.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction
T2 - Nationwide survey in Japan
AU - Hashizume, Naoki
AU - Yagi, Minoru
AU - Ushijima, Kosuke
AU - Seki, Yoshitaka
AU - Fukahori, Suguru
AU - Muto, Mitsuru
AU - Matsufuji, Hiroshi
AU - Taguchi, Tomoaki
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of CIPO patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric CIPO in Japan. Methods: In 2012, a nationwide survey was conducted to identify the clinical presentation of CIPO in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: “probiotics”, “Japanese herbal medicines (Kampo medicines)”, “laxatives”, and “prokinetics”. Results: Ninety-two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty-four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70% of whom were treated specifically with mosapride. Conclusion: Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat CIPO in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric CIPO in Japan.
AB - Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of CIPO patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric CIPO in Japan. Methods: In 2012, a nationwide survey was conducted to identify the clinical presentation of CIPO in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: “probiotics”, “Japanese herbal medicines (Kampo medicines)”, “laxatives”, and “prokinetics”. Results: Ninety-two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty-four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70% of whom were treated specifically with mosapride. Conclusion: Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat CIPO in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric CIPO in Japan.
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UR - http://www.scopus.com/inward/citedby.url?scp=85011665445&partnerID=8YFLogxK
U2 - 10.1111/ped.13201
DO - 10.1111/ped.13201
M3 - Article
C2 - 27862707
AN - SCOPUS:85011665445
VL - 59
SP - 467
EP - 472
JO - Pediatrics International
JF - Pediatrics International
SN - 1328-8067
IS - 4
ER -