Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction: Nationwide survey in Japan

Naoki Hashizume, Minoru Yagi, Kosuke Ushijima, Yoshitaka Seki, Suguru Fukahori, Mitsuru Muto, Hiroshi Matsufuji, Tomoaki Taguchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of CIPO patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric CIPO in Japan. Methods: In 2012, a nationwide survey was conducted to identify the clinical presentation of CIPO in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: “probiotics”, “Japanese herbal medicines (Kampo medicines)”, “laxatives”, and “prokinetics”. Results: Ninety-two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty-four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70% of whom were treated specifically with mosapride. Conclusion: Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat CIPO in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric CIPO in Japan.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalPediatrics International
Volume59
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Fingerprint

Intestinal Pseudo-Obstruction
Kampo Medicine
Japan
Pediatrics
Drug Therapy
Probiotics
Laxatives
Peristalsis
Herbal Medicine
Traditional Medicine
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction : Nationwide survey in Japan. / Hashizume, Naoki; Yagi, Minoru; Ushijima, Kosuke; Seki, Yoshitaka; Fukahori, Suguru; Muto, Mitsuru; Matsufuji, Hiroshi; Taguchi, Tomoaki.

In: Pediatrics International, Vol. 59, No. 4, 01.04.2017, p. 467-472.

Research output: Contribution to journalArticle

Hashizume, N, Yagi, M, Ushijima, K, Seki, Y, Fukahori, S, Muto, M, Matsufuji, H & Taguchi, T 2017, 'Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction: Nationwide survey in Japan', Pediatrics International, vol. 59, no. 4, pp. 467-472. https://doi.org/10.1111/ped.13201
Hashizume, Naoki ; Yagi, Minoru ; Ushijima, Kosuke ; Seki, Yoshitaka ; Fukahori, Suguru ; Muto, Mitsuru ; Matsufuji, Hiroshi ; Taguchi, Tomoaki. / Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction : Nationwide survey in Japan. In: Pediatrics International. 2017 ; Vol. 59, No. 4. pp. 467-472.
@article{da84eb61ff6e4c0b872912228ba2fdeb,
title = "Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction: Nationwide survey in Japan",
abstract = "Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of CIPO patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric CIPO in Japan. Methods: In 2012, a nationwide survey was conducted to identify the clinical presentation of CIPO in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: “probiotics”, “Japanese herbal medicines (Kampo medicines)”, “laxatives”, and “prokinetics”. Results: Ninety-two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty-four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70{\%} of whom were treated specifically with mosapride. Conclusion: Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat CIPO in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric CIPO in Japan.",
author = "Naoki Hashizume and Minoru Yagi and Kosuke Ushijima and Yoshitaka Seki and Suguru Fukahori and Mitsuru Muto and Hiroshi Matsufuji and Tomoaki Taguchi",
year = "2017",
month = "4",
day = "1",
doi = "10.1111/ped.13201",
language = "English",
volume = "59",
pages = "467--472",
journal = "Pediatrics International",
issn = "1328-8067",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction

T2 - Nationwide survey in Japan

AU - Hashizume, Naoki

AU - Yagi, Minoru

AU - Ushijima, Kosuke

AU - Seki, Yoshitaka

AU - Fukahori, Suguru

AU - Muto, Mitsuru

AU - Matsufuji, Hiroshi

AU - Taguchi, Tomoaki

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of CIPO patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric CIPO in Japan. Methods: In 2012, a nationwide survey was conducted to identify the clinical presentation of CIPO in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: “probiotics”, “Japanese herbal medicines (Kampo medicines)”, “laxatives”, and “prokinetics”. Results: Ninety-two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty-four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70% of whom were treated specifically with mosapride. Conclusion: Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat CIPO in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric CIPO in Japan.

AB - Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of CIPO patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric CIPO in Japan. Methods: In 2012, a nationwide survey was conducted to identify the clinical presentation of CIPO in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: “probiotics”, “Japanese herbal medicines (Kampo medicines)”, “laxatives”, and “prokinetics”. Results: Ninety-two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty-four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70% of whom were treated specifically with mosapride. Conclusion: Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat CIPO in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric CIPO in Japan.

UR - http://www.scopus.com/inward/record.url?scp=85011665445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011665445&partnerID=8YFLogxK

U2 - 10.1111/ped.13201

DO - 10.1111/ped.13201

M3 - Article

C2 - 27862707

AN - SCOPUS:85011665445

VL - 59

SP - 467

EP - 472

JO - Pediatrics International

JF - Pediatrics International

SN - 1328-8067

IS - 4

ER -