Phase decomposition of a cell passing through a μ-channel: A method for improving the evaluation of cell stiffness

Chia Hung Dylan Tsai, Makoto Kaneko, Shinya Sakuma, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Two-phase motion of a cell inside a μ-channel is observed by the high-speed vision system. Two phases are defined as the phase of deformation and the phase of constant shape according to their characteristics. Red blood cells were used for experimental validation, and a mechanical model consisting of a spring and a damper in parallel is utilized for interpreting the behavior of the RBCs. An analysis method for acquiring the transition point between two phases is proposed, and is utilized in the analysis of the experimental results presented in this paper. Two different initial velocities of red blood cells approaching the μ-channel were used in the experiment. The experimental results show that the red blood cells with the higher initial velocity require longer distance to reach the steady state comparing to the ones with the lower initial velocity.

Original languageEnglish
Title of host publication2012 IEEE International Conference on Mechatronics and Automation, ICMA 2012
Pages138-143
Number of pages6
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event2012 9th IEEE International Conference on Mechatronics and Automation, ICMA 2012 - Chengdu, China
Duration: Aug 5 2012Aug 8 2012

Publication series

Name2012 IEEE International Conference on Mechatronics and Automation, ICMA 2012

Conference

Conference2012 9th IEEE International Conference on Mechatronics and Automation, ICMA 2012
Country/TerritoryChina
CityChengdu
Period8/5/128/8/12

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Mechanical Engineering

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