Phenotypic expression of gastrointestinal differentiation markers in colorectal adenocarcinomas with liver metastasis

Takashi Yao, Miyuki Takata, Shuichi Tustsumi, Ken Ichi Nishiyama, Ken Ichi Taguchi, Eishi Nagai, Masazumi Tsuneyoshi

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Abstract

Aim: The purpose of the present study was to clarify the correlation between phenotypic expression of gastrointestinal differentiation markers and colorectal cancer behaviour, particularly invasion and hepatic metastasis. Methods: Thirty-one cases of advanced colorectal adenocarcinoma (CRC) with liver metastasis were selected. Phenotypic patterns were evaluated immunohistochemically by means of antibodies to CD10, MUC2, and human gastric mucin (HGM). Results: The incidence of MUC2 (45.2%) and HGM (16.1%) expression in CRCs with liver metastasis did not differ from non-metastatic CRCs. In contrast, the incidence of CD10 expression was significantly higher in CRCs with liver metastasis (58.1%) than in control CRCs (21.7%). Phenotypic expression in the liver metastasis carcinomas was similar to that of the primary lesions. Conclusions: The findings suggest that cases of CRC with CD10 expression are at increased risk of liver metastasis. Even if there is no liver metastasis at laparotomy for CRC, careful follow-up is recommended for CRCs with CD10 expression.

Original languageEnglish
Pages (from-to)556-560
Number of pages5
JournalPathology
Volume34
Issue number6
DOIs
Publication statusPublished - Dec 2002

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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    Yao, T., Takata, M., Tustsumi, S., Nishiyama, K. I., Taguchi, K. I., Nagai, E., & Tsuneyoshi, M. (2002). Phenotypic expression of gastrointestinal differentiation markers in colorectal adenocarcinomas with liver metastasis. Pathology, 34(6), 556-560. https://doi.org/10.1080/0031302021000035965-4