Phenylboronic acid-based 19 F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change

Hiroshi Nonaka, Qi An, Fuminori Sugihara, Tomohiro Doura, Akira Tsuchiya, Yoshichika Yoshioka, Shinsuke Sando

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Herein, we report on a new 19 F MRI probe for the detection and imaging of H 2 O 2 . Our designed 2-fluorophenylboronic acid-based 19 F probe promptly reacted with H 2 O 2 to produce 2-fluorophenol via boronic acid oxidation. The accompanying 19 F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H 2 O 2 by 19 F chemical-shift-selective MRI.

Original languageEnglish
Pages (from-to)331-335
Number of pages5
Journalanalytical sciences
Volume31
Issue number4
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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