Phenylboronic acid-based                          19                         F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change

Hiroshi Nonaka; Qi An; Fuminori Sugihara; Tomohiro Doura; Akira Tsuchiya; Yoshichika Yoshioka; Shinsuke Sando

doi:10.2116/analsci.31.331

Phenylboronic acid-based ¹⁹ F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change

Hiroshi Nonaka, Qi An, Fuminori Sugihara, Tomohiro Doura, Akira Tsuchiya, Yoshichika Yoshioka, Shinsuke Sando

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Abstract

Herein, we report on a new ¹⁹ F MRI probe for the detection and imaging of H ₂ O ₂ . Our designed 2-fluorophenylboronic acid-based ¹⁹ F probe promptly reacted with H ₂ O ₂ to produce 2-fluorophenol via boronic acid oxidation. The accompanying ¹⁹ F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H ₂ O ₂ by ¹⁹ F chemical-shift-selective MRI.

Original language	English
Pages (from-to)	331-335
Number of pages	5
Journal	analytical sciences
Volume	31
Issue number	4
DOIs	https://doi.org/10.2116/analsci.31.331
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Analytical Chemistry

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10.2116/analsci.31.331

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Nonaka, H., An, Q., Sugihara, F., Doura, T., Tsuchiya, A., Yoshioka, Y., & Sando, S. (2015). Phenylboronic acid-based ¹⁹ F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change analytical sciences, 31(4), 331-335. https://doi.org/10.2116/analsci.31.331

Phenylboronic acid-based ¹⁹ F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change . / Nonaka, Hiroshi; An, Qi; Sugihara, Fuminori et al.
In: analytical sciences, Vol. 31, No. 4, 2015, p. 331-335.

Research output: Contribution to journal › Article › peer-review

Nonaka, H, An, Q, Sugihara, F, Doura, T, Tsuchiya, A, Yoshioka, Y & Sando, S 2015, ' Phenylboronic acid-based ¹⁹ F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change ', analytical sciences, vol. 31, no. 4, pp. 331-335. https://doi.org/10.2116/analsci.31.331

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abstract = " Herein, we report on a new 19 F MRI probe for the detection and imaging of H 2 O 2 . Our designed 2-fluorophenylboronic acid-based 19 F probe promptly reacted with H 2 O 2 to produce 2-fluorophenol via boronic acid oxidation. The accompanying 19 F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H 2 O 2 by 19 F chemical-shift-selective MRI. ",

author = "Hiroshi Nonaka and Qi An and Fuminori Sugihara and Tomohiro Doura and Akira Tsuchiya and Yoshichika Yoshioka and Shinsuke Sando",

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AU - Doura, Tomohiro

AU - Tsuchiya, Akira

AU - Yoshioka, Yoshichika

AU - Sando, Shinsuke

PY - 2015

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Phenylboronic acid-based ¹⁹ F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change

Abstract

All Science Journal Classification (ASJC) codes

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