Phosphate anion chelation and base-pairing. Design of receptors and carriers for nucleotides and nucleotide analogues

Jonathan L. Sessler, Hiroyuki Furuta, Vladimir Kral

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

A rational approach to the development of effective carriers for the through-membrane transport of GMP (guanosine 5 -monophosphate) at neutral pH is described. The approach detailed is a ditopic one predicated on the use of nucleic acid-base ‘nucleobase’ subunits to provide stabilizing hydrogen bonding interactions and the use of expanded porphyrin anion binding subunits to provide phosphate chelation. Appropriate background studies along with the synthesis of a functioning state-of-the-art system are reported. In addition, the reasons for preparing such GMP transport systems are presented in full.

Original languageEnglish
Pages (from-to)209-220
Number of pages12
JournalSupramolecular Chemistry
Volume1
Issue number3-4
DOIs
Publication statusPublished - Jan 1 1993
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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