Phosphatidylserine synthase I and II of mammalian cells

Osamu Kuge, Masahiro Nishijima

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Phosphatidylserine (PtdSer) in mammalian cells is synthesized through an exchange of free L-serine for the base moiety of pre-existing phospholipids. Studies on PtdSer biosynthesis in Chinese hamster ovary (CHO) cells have suggested that the serine base-exchange is catalyzed by at least two different enzymes; one, named PtdSer synthase I (PSS I), uses phosphatidylcholine (PtdCho) and possibly phosphatidylethanolamine (PtdEtn) as phosphatidyl donors for the serine base-exchange, and the other, named PtdSer synthase II (PSS II), uses PtdEtn but not PtdCho as a phosphatidyl donor. Recently, cDNAs of the PSS I and II have been isolated from CHO-K1 cells. This review will briefly describe the current understanding of PtdSer synthases of mammalian cells, mainly CHO cells.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalBiochimica et Biophysica Acta - Lipids and Lipid Metabolism
Volume1348
Issue number1-2
DOIs
Publication statusPublished - Sep 4 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Endocrinology

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