Abstract
We show that the Sendai virus C' and C proteins exist as both phosphorylated and nonphosphorylated forms, while the Y1 and Y2 proteins are not phosphorylated in virus-infected cells. Phosphorylation occurs primarily on serine residues, most likely at the N-terminus of the C' and C proteins. Phosphatases PP1 and PP2A significantly modulate the phosphorylation status of the C proteins as evidenced by okadaic acid inhibition of these phosphatases. The other Sendai virus proteins including the cotranslationally expressed P protein are not necessary for the appropriate phosphorylation of the C' and C proteins. Differential phosphorylation and potential for the modulation of phosphorylation suggests regulatory functions for the C proteins.
Original language | English |
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Article number | 71615 |
Pages (from-to) | 471-474 |
Number of pages | 4 |
Journal | Virology |
Volume | 197 |
Issue number | 1 |
DOIs | |
Publication status | Published - Nov 1993 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Virology