Phosphorylation of the Sendai virus C proteins

Dana D. Hendricks, Etsuro Ono, Jerome M. Sever, Kailash C. Gupta

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We show that the Sendai virus C' and C proteins exist as both phosphorylated and nonphosphorylated forms, while the Y1 and Y2 proteins are not phosphorylated in virus-infected cells. Phosphorylation occurs primarily on serine residues, most likely at the N-terminus of the C' and C proteins. Phosphatases PP1 and PP2A significantly modulate the phosphorylation status of the C proteins as evidenced by okadaic acid inhibition of these phosphatases. The other Sendai virus proteins including the cotranslationally expressed P protein are not necessary for the appropriate phosphorylation of the C' and C proteins. Differential phosphorylation and potential for the modulation of phosphorylation suggests regulatory functions for the C proteins.

Original languageEnglish
Article number71615
Pages (from-to)471-474
Number of pages4
JournalVirology
Volume197
Issue number1
DOIs
Publication statusPublished - Nov 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology

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