TY - JOUR
T1 - Phosphorylcholine-endcapped oligomer and block co-oligomer and surface biological reactivity
AU - Matsuda, Takehisa
AU - Nagase, Junichi
AU - Ghoda, Akane
AU - Hirano, Yoshiaki
AU - Kidoaki, Satoru
AU - Nakayama, Yasuhide
N1 - Funding Information:
This study was financially supported by the Promotion of Fundamental Studies of Health Science of the Organization for Pharmaceutical Safety and Research (OPSR) under grant no. 97-15, and in part by a Grant-in-Aid for Scientific Research (A2-12358017, B2-12470277) from Ministry of Education, Culture, Sports, Science, and Technology of Japan.
PY - 2003/11
Y1 - 2003/11
N2 - Phosphorylcholine (PC)-endcapped oligomer and block co-oligomer were prepared by employing a photoiniferter-based quasi-living polymerization technique. The designed oligomer had a PC polar head group attached to an alkylene chain at one end of the molecule and an oligo(styrene) (oligoST) segment at the other end. In the co-oligomer, an oligo(N,N-dimethylacrylamide) (oligoDMAAm) segment was inserted between both ends of the oligomer mentioned above. Surface coating of these amphiphilic substances, using an appropriate coating procedure, resulted in a very hydrophilic characteristic, suggesting that the oligoST anchored on the substrate and the PC polar head group was exposed to or located on the outer coating layer. Non-cell adhesivity in serum-containing medium was observed, while slightly reduced protein adsorption was observed. Thus, PC-endcapped oligomer and block co-oligomer appear to function as a biocompatible coating.
AB - Phosphorylcholine (PC)-endcapped oligomer and block co-oligomer were prepared by employing a photoiniferter-based quasi-living polymerization technique. The designed oligomer had a PC polar head group attached to an alkylene chain at one end of the molecule and an oligo(styrene) (oligoST) segment at the other end. In the co-oligomer, an oligo(N,N-dimethylacrylamide) (oligoDMAAm) segment was inserted between both ends of the oligomer mentioned above. Surface coating of these amphiphilic substances, using an appropriate coating procedure, resulted in a very hydrophilic characteristic, suggesting that the oligoST anchored on the substrate and the PC polar head group was exposed to or located on the outer coating layer. Non-cell adhesivity in serum-containing medium was observed, while slightly reduced protein adsorption was observed. Thus, PC-endcapped oligomer and block co-oligomer appear to function as a biocompatible coating.
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U2 - 10.1016/S0142-9612(03)00344-2
DO - 10.1016/S0142-9612(03)00344-2
M3 - Article
C2 - 12922161
AN - SCOPUS:0042561997
SN - 0142-9612
VL - 24
SP - 4517
EP - 4527
JO - Biomaterials
JF - Biomaterials
IS - 24
ER -