Photochemical generation of C4'-oxidized abasic site containing oligonucleotide and its amine modification reaction.

Kazuteru Usui, Mariko Aso, Yukiko Toguchi, Yoshie Kakihara, Tsuyoshi Goromaru, Hiroshi Suemune

Research output: Contribution to journalMeeting Abstract

Abstract

We studied photochemical generation of oligodeoxynucleotide (ODN) containing C4'-oxidized abasic site (1) from its caged precursor 3. Photoirradiation of 3 at 365 nm followed by amine treatment under neutral conditions afforded the lactam (2) efficiently. Duplexed ODN 3 was converted to 1 faster and more efficiently than single stranded 3, whereas amine treatment of 1 formed from single stranded 3 resulted in slightly faster lactam formation than with duplex.

Original languageEnglish
Pages (from-to)169-170
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number50
Publication statusPublished - Jan 1 2006

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Lactams
Oligodeoxyribonucleotides
Oligonucleotides
Amines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Photochemical generation of C4'-oxidized abasic site containing oligonucleotide and its amine modification reaction. / Usui, Kazuteru; Aso, Mariko; Toguchi, Yukiko; Kakihara, Yoshie; Goromaru, Tsuyoshi; Suemune, Hiroshi.

In: Nucleic acids symposium series (2004), No. 50, 01.01.2006, p. 169-170.

Research output: Contribution to journalMeeting Abstract

Usui, Kazuteru ; Aso, Mariko ; Toguchi, Yukiko ; Kakihara, Yoshie ; Goromaru, Tsuyoshi ; Suemune, Hiroshi. / Photochemical generation of C4'-oxidized abasic site containing oligonucleotide and its amine modification reaction. In: Nucleic acids symposium series (2004). 2006 ; No. 50. pp. 169-170.
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