Photodynamic antisense therapy: regulation of cervical carcinoma cells by psoralen-conjugated oligonucleotides.

Asako Yamayoshi, Kiyoko Kato, Reiko Iwase, Tetsuji Yamaoka, Norio Wake, Akira Murakami

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To reinforce antisense effects, we focused on the photo-cross-linking ability of psoralen derivatives and examined the applicability of the photodynamic antisense therapy to cancer cells using psoralen-conjugated oligo(nucleosides phosphorothioate)s (Ps-S-Oligo). The regulatory effects of Ps-S-Oligos on the proliferation of cervical carcinoma were evaluated. The inhibitory effects were found to be significant (IC50=16 nM) without any drug delivery systems, and it was also found that the mechanism was associated with the p53 induced apoptosis. This result suggests that the photodynamic antisense therapy will be a promising concept for the cancer therapy.

Original languageEnglish
Pages (from-to)75-76
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number3
Publication statusPublished - Jan 1 2003
Externally publishedYes

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