TY - JOUR
T1 - Photolytic Protein Aggregates
T2 - Versatile Materials for Controlled Release of Active Proteins
AU - Ishiwatari, Akira
AU - Yamaguchi, Satoshi
AU - Takamori, Satoshi
AU - Yamahira, Shinya
AU - Minamihata, Kosuke
AU - Nagamune, Teruyuki
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2016/5/11
Y1 - 2016/5/11
N2 - Photolytic protein aggregates are developed as a facile and versatile platform for light-induced release of active proteins. The proteins modified with biotin through a photo-cleavable linker rapidly form aggregates with streptavidin and biotinylated functional molecules simply by mixing. Light irradiation releases active proteins from the aggregates in high yields, and light-induced uptake of drug-modified transferrin into living cells is successfully demonstrated.
AB - Photolytic protein aggregates are developed as a facile and versatile platform for light-induced release of active proteins. The proteins modified with biotin through a photo-cleavable linker rapidly form aggregates with streptavidin and biotinylated functional molecules simply by mixing. Light irradiation releases active proteins from the aggregates in high yields, and light-induced uptake of drug-modified transferrin into living cells is successfully demonstrated.
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U2 - 10.1002/adhm.201500957
DO - 10.1002/adhm.201500957
M3 - Article
C2 - 26945901
AN - SCOPUS:84959518795
SN - 2192-2640
VL - 5
SP - 1002
EP - 1007
JO - Advanced healthcare materials
JF - Advanced healthcare materials
IS - 9
ER -