Photolytic Protein Aggregates: Versatile Materials for Controlled Release of Active Proteins

Akira Ishiwatari, Satoshi Yamaguchi, Satoshi Takamori, Shinya Yamahira, Kosuke Minamihata, Teruyuki Nagamune

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Photolytic protein aggregates are developed as a facile and versatile platform for light-induced release of active proteins. The proteins modified with biotin through a photo-cleavable linker rapidly form aggregates with streptavidin and biotinylated functional molecules simply by mixing. Light irradiation releases active proteins from the aggregates in high yields, and light-induced uptake of drug-modified transferrin into living cells is successfully demonstrated.

Original languageEnglish
Pages (from-to)1002-1007
Number of pages6
JournalAdvanced Healthcare Materials
Volume5
Issue number9
DOIs
Publication statusPublished - May 11 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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