Photoperiodic changes in hypothalamic insulin receptor gene expression are regulated by gonadal testosterone

Tsubasa Anraku, Tsuyoshi Takagi, Nobuhiro Nakao, Miwa Watanabe, Shinobu Yasuo, Yasuhiro Katou, Yukihiro Ueda, Atsushi Murai, Masayuki Iigo, Shizufumi Ebihara, Takashi Yoshimura

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5 Citations (Scopus)

Abstract

In order to adapt to seasonal changes, animals exhibit robust changes in their reproductive status, body weight, and molt. However, the molecular mechanisms regulating such seasonal changes in physiology and behavior are not fully understood. Here, we report the photoperiodic regulation of the insulin receptor (IR) gene in the infundibular nucleus (anatomically homologous to the mammalian arcuate nucleus) of the Japanese quail. When the birds were transferred from short-day to long-day conditions, a significant increase in the level of IR mRNA was observed on the 10th long day, whereas that in testicular length was observed on the 5th long day. Castration abolished IR mRNA expression induced by long-day conditions, whereas the testosterone administration mimicked induction of IR mRNA expression induced by long-day conditions. These results suggested that the photoperiodic regulation of the IR mRNA in the infundibular nucleus is mediated by testosterone from the testes. It has been known that the central administration of insulin increases luteinizing hormone (LH) secretion, and neuron-specific disruption of IR gene causes impaired gonadal function due to the dysregulation of LH and increased food intake and body weight. Together with these results, the photoperiodic regulation of the IR mRNA in the hypothalamus may enhance the effect of long days in the seasonal response of reproduction and body weight changes.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalBrain Research
Volume1163
Issue number1
DOIs
Publication statusPublished - Aug 13 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Anraku, T., Takagi, T., Nakao, N., Watanabe, M., Yasuo, S., Katou, Y., Ueda, Y., Murai, A., Iigo, M., Ebihara, S., & Yoshimura, T. (2007). Photoperiodic changes in hypothalamic insulin receptor gene expression are regulated by gonadal testosterone. Brain Research, 1163(1), 86-90. https://doi.org/10.1016/j.brainres.2007.06.028