Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice

Tsuyoshi Otsuka, Misato Kawai, Yuki Togo, Ryosei Goda, Takahiro Kawase, Haruka Matsuo, Ayaka Iwamoto, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasuo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Seasonal affective disorder (SAD) is characterized by depression during specific seasons, generally winter. The pathophysiological mechanisms underlying SAD remain elusive due to a limited number of animal models with high availability and validity. Here we show that laboratory C57BL/6J mice display photoperiodic changes in depression-like behavior and brain serotonin content. C57BL/6J mice maintained under short-day conditions, as compared to those under long-day conditions, demonstrated prolonged immobility times in the forced swimming test with lower brain levels of serotonin and its precursor l-tryptophan. Furthermore, photoperiod altered multiple parameters reflective of peripheral metabolism, including the ratio of plasma l-tryptophan to the sum of other large neutral amino acids that compete for transport across the blood-brain barrier, responses of circulating glucose and insulin to glucose load, sucrose intake under restricted feeding condition, and sensitivity of the brain serotonergic system to peripherally administered glucose. These data suggest that the mechanisms underlying SAD involve the brain-peripheral tissue network, and C57BL/6J mice can serve as a powerful tool for investigating the link between seasons and mood.

Original languageEnglish
Pages (from-to)37-47
Number of pages11
JournalPsychoneuroendocrinology
Volume40
Issue number1
DOIs
Publication statusPublished - Feb 5 2014

Fingerprint

Seasonal Affective Disorder
Inbred C57BL Mouse
Depression
Brain
Glucose
Tryptophan
Serotonin
Neutral Amino Acids
Photoperiod
Blood-Brain Barrier
Sucrose
Animal Models
Insulin

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice. / Otsuka, Tsuyoshi; Kawai, Misato; Togo, Yuki; Goda, Ryosei; Kawase, Takahiro; Matsuo, Haruka; Iwamoto, Ayaka; Nagasawa, Mao; Furuse, Mitsuhiro; Yasuo, Shinobu.

In: Psychoneuroendocrinology, Vol. 40, No. 1, 05.02.2014, p. 37-47.

Research output: Contribution to journalArticle

Otsuka, Tsuyoshi ; Kawai, Misato ; Togo, Yuki ; Goda, Ryosei ; Kawase, Takahiro ; Matsuo, Haruka ; Iwamoto, Ayaka ; Nagasawa, Mao ; Furuse, Mitsuhiro ; Yasuo, Shinobu. / Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice. In: Psychoneuroendocrinology. 2014 ; Vol. 40, No. 1. pp. 37-47.
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