Photostable iodinated silica/porphyrin hybrid nanoparticles with heavy-atom effect for wide-field photodynamic/photothermal therapy using single light source

Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Toshinari Kori, Kazunori Ishimura

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Physical therapies including photodynamic therapy (PDT) and photothermal therapy (PTT) can be effective against diseases that are resistant to chemotherapy and remain as incurable malignancies (for example, multiple myeloma). In this study, to enhance the treatment efficacy for multiple myeloma using the synergetic effect brought about by combining PDT and PTT, iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs) with high photostability are developed. They can generate both 1O2 and heat with irradiation from a light-emitting diode (LED), acting as photosensitizers for PDT/PTT combination treatment. ISP HNPs exhibit the external heavy atom effect, which significantly improves both the quantum yield for 1O 2 generation and the light-to-heat conversion efficiency. The in vivo fluorescence imaging demonstrates that ISP HNPs, modified with folic acid and polyethylene glycol (FA-PEG-ISP HNPs), locally accumulate in the tumor after 18 h of their intravenous injection into tumor-bearing mice. The LED irradiation on the tumor area of the mice injected with FA-PEG-ISP HNPs causes necrosis of the tumor tissues, resulting in the inhibition of tumor growth and an improvement in the survival rate.

Original languageEnglish
Pages (from-to)503-513
Number of pages11
JournalAdvanced Functional Materials
Volume24
Issue number4
DOIs
Publication statusPublished - Jan 29 2014

Fingerprint

Photodynamic therapy
Porphyrins
porphyrins
Silicon Dioxide
Light sources
Tumors
therapy
light sources
Silica
Nanoparticles
silicon dioxide
Atoms
nanoparticles
tumors
Polyethylene glycols
atoms
Light emitting diodes
Bearings (structural)
Irradiation
Physical therapy

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Photostable iodinated silica/porphyrin hybrid nanoparticles with heavy-atom effect for wide-field photodynamic/photothermal therapy using single light source. / Hayashi, Koichiro; Nakamura, Michihiro; Miki, Hirokazu; Ozaki, Shuji; Abe, Masahiro; Matsumoto, Toshio; Kori, Toshinari; Ishimura, Kazunori.

In: Advanced Functional Materials, Vol. 24, No. 4, 29.01.2014, p. 503-513.

Research output: Contribution to journalArticle

Hayashi, Koichiro ; Nakamura, Michihiro ; Miki, Hirokazu ; Ozaki, Shuji ; Abe, Masahiro ; Matsumoto, Toshio ; Kori, Toshinari ; Ishimura, Kazunori. / Photostable iodinated silica/porphyrin hybrid nanoparticles with heavy-atom effect for wide-field photodynamic/photothermal therapy using single light source. In: Advanced Functional Materials. 2014 ; Vol. 24, No. 4. pp. 503-513.
@article{6f762d3f5bd34357975b32a40eebea93,
title = "Photostable iodinated silica/porphyrin hybrid nanoparticles with heavy-atom effect for wide-field photodynamic/photothermal therapy using single light source",
abstract = "Physical therapies including photodynamic therapy (PDT) and photothermal therapy (PTT) can be effective against diseases that are resistant to chemotherapy and remain as incurable malignancies (for example, multiple myeloma). In this study, to enhance the treatment efficacy for multiple myeloma using the synergetic effect brought about by combining PDT and PTT, iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs) with high photostability are developed. They can generate both 1O2 and heat with irradiation from a light-emitting diode (LED), acting as photosensitizers for PDT/PTT combination treatment. ISP HNPs exhibit the external heavy atom effect, which significantly improves both the quantum yield for 1O 2 generation and the light-to-heat conversion efficiency. The in vivo fluorescence imaging demonstrates that ISP HNPs, modified with folic acid and polyethylene glycol (FA-PEG-ISP HNPs), locally accumulate in the tumor after 18 h of their intravenous injection into tumor-bearing mice. The LED irradiation on the tumor area of the mice injected with FA-PEG-ISP HNPs causes necrosis of the tumor tissues, resulting in the inhibition of tumor growth and an improvement in the survival rate.",
author = "Koichiro Hayashi and Michihiro Nakamura and Hirokazu Miki and Shuji Ozaki and Masahiro Abe and Toshio Matsumoto and Toshinari Kori and Kazunori Ishimura",
year = "2014",
month = "1",
day = "29",
doi = "10.1002/adfm.201301771",
language = "English",
volume = "24",
pages = "503--513",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley-VCH Verlag",
number = "4",

}

TY - JOUR

T1 - Photostable iodinated silica/porphyrin hybrid nanoparticles with heavy-atom effect for wide-field photodynamic/photothermal therapy using single light source

AU - Hayashi, Koichiro

AU - Nakamura, Michihiro

AU - Miki, Hirokazu

AU - Ozaki, Shuji

AU - Abe, Masahiro

AU - Matsumoto, Toshio

AU - Kori, Toshinari

AU - Ishimura, Kazunori

PY - 2014/1/29

Y1 - 2014/1/29

N2 - Physical therapies including photodynamic therapy (PDT) and photothermal therapy (PTT) can be effective against diseases that are resistant to chemotherapy and remain as incurable malignancies (for example, multiple myeloma). In this study, to enhance the treatment efficacy for multiple myeloma using the synergetic effect brought about by combining PDT and PTT, iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs) with high photostability are developed. They can generate both 1O2 and heat with irradiation from a light-emitting diode (LED), acting as photosensitizers for PDT/PTT combination treatment. ISP HNPs exhibit the external heavy atom effect, which significantly improves both the quantum yield for 1O 2 generation and the light-to-heat conversion efficiency. The in vivo fluorescence imaging demonstrates that ISP HNPs, modified with folic acid and polyethylene glycol (FA-PEG-ISP HNPs), locally accumulate in the tumor after 18 h of their intravenous injection into tumor-bearing mice. The LED irradiation on the tumor area of the mice injected with FA-PEG-ISP HNPs causes necrosis of the tumor tissues, resulting in the inhibition of tumor growth and an improvement in the survival rate.

AB - Physical therapies including photodynamic therapy (PDT) and photothermal therapy (PTT) can be effective against diseases that are resistant to chemotherapy and remain as incurable malignancies (for example, multiple myeloma). In this study, to enhance the treatment efficacy for multiple myeloma using the synergetic effect brought about by combining PDT and PTT, iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs) with high photostability are developed. They can generate both 1O2 and heat with irradiation from a light-emitting diode (LED), acting as photosensitizers for PDT/PTT combination treatment. ISP HNPs exhibit the external heavy atom effect, which significantly improves both the quantum yield for 1O 2 generation and the light-to-heat conversion efficiency. The in vivo fluorescence imaging demonstrates that ISP HNPs, modified with folic acid and polyethylene glycol (FA-PEG-ISP HNPs), locally accumulate in the tumor after 18 h of their intravenous injection into tumor-bearing mice. The LED irradiation on the tumor area of the mice injected with FA-PEG-ISP HNPs causes necrosis of the tumor tissues, resulting in the inhibition of tumor growth and an improvement in the survival rate.

UR - http://www.scopus.com/inward/record.url?scp=84892950115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892950115&partnerID=8YFLogxK

U2 - 10.1002/adfm.201301771

DO - 10.1002/adfm.201301771

M3 - Article

AN - SCOPUS:84892950115

VL - 24

SP - 503

EP - 513

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

IS - 4

ER -