TY - JOUR
T1 - Photothermal molecular sensing by using metal thin-film nanograting for chemical and biomedical applications
AU - Okamoto, Koichi
AU - Zhang, Zhaoyu
AU - Wei, David T.
AU - Scherer, Axel
N1 - Funding Information:
The authors would like to thank Prof. M. Terazima of Kyoto University for valuable suggestions and discussions. We also thank Dr. T. Yoshie of Caltech for helping the nanofabrication. A part of this study was supported by AFOSR (F49620-03-1-0418).
PY - 2004/12/22
Y1 - 2004/12/22
N2 - We have developed a highly sensitive molecular sensor based on the heterodyne-detected third order nonlinear optical measurement with metal thin-film gratings. Pumped by an ultra-violet laser, the stripe pattern of the grating is transferred to the sample solution. The properties of the solution are detected via probe beam diffraction output from this special modulation. Time dependent signals profiles in nitrobenzene/2-propanol solution are thus obtained. The signal intensities as well as the concentrations of solute are proportional to the induced third order nonlinear electric susceptibility of solution. This technique can even detect the properties of those molecules and chemical compounds which are colorless and non-fluorescent. The merits of this method, such as simplicity, the high sensitivity, and the high speed, should be suitable for the molecular sensor of the microfluidic devices.
AB - We have developed a highly sensitive molecular sensor based on the heterodyne-detected third order nonlinear optical measurement with metal thin-film gratings. Pumped by an ultra-violet laser, the stripe pattern of the grating is transferred to the sample solution. The properties of the solution are detected via probe beam diffraction output from this special modulation. Time dependent signals profiles in nitrobenzene/2-propanol solution are thus obtained. The signal intensities as well as the concentrations of solute are proportional to the induced third order nonlinear electric susceptibility of solution. This technique can even detect the properties of those molecules and chemical compounds which are colorless and non-fluorescent. The merits of this method, such as simplicity, the high sensitivity, and the high speed, should be suitable for the molecular sensor of the microfluidic devices.
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U2 - 10.1016/j.tsf.2004.06.173
DO - 10.1016/j.tsf.2004.06.173
M3 - Article
AN - SCOPUS:10044256453
SN - 0040-6090
VL - 469-470
SP - 420
EP - 424
JO - Thin Solid Films
JF - Thin Solid Films
IS - SPEC. ISS.
ER -